摘要
目的探讨C—erbB-2、p53、雌激素受体（ER）、孕激素受体（PR）在乳腺癌中的表达及其临床意义。方法采用免疫组织化学SP方法检测43例乳腺癌病例中C—erbB-2、p53、ER、PR的表达，并分析其临床意义。结果43例乳腺癌中C—erbB-2、p53、ER、PR的阳性表达率分别为76．7％、39．5％、41．9％、51．2％，p53、ER、PR的阳性表达率在患者年龄、有无淋巴结转移及组织学类型之间差异无统计学意义（P〉0．05），C—erbB-2表达率在有无淋巴结转移之间差异有统计学意义（P〈0．05），在患者年龄、肿瘤体积及组织学类型之间差异无统计学意义（P〉0．05）；ER、PR与C—erbB-2表达一致率为51．2％，表达不一致率为48．8％，p53与C—erbB-2表达一致率为53．5％，表达不一致率为46．5％，p53、ER、PR表达与C—erbB-2表达无显著相关性（P〉0．05）。结论C—erbB-2的阳性表达是乳腺癌患者预后差的指标，联合检测p53、ER、PR更有助于乳腺癌患者的临床治疗和预后判断。
Objective To investigate the expressions of C - erbB - 2, p53, estrogen receptor （ER）, progesterone reeeptor（PR） in breast cancer tissue and their clinical significance. Methods The expressions of C - erbB - 2, p53, ER, PR in 43 cases of breast cancer tissue were detected by immunohistochemistry, and their clinical significance were statistically analyzed. Results Positive expression rate of C - erbB -2, p53, ER, PR in 43 cases of breast cancer tissue were 76.7%, 39.5%, 41.9% , 51.2%. There were no difference of the expressions of p53, ER, PR in age, tumor volume and the histology type of breast cancers （ P 〉 0.05 ）, There was difference of expression of C - erbB - 2 in lymph node status（P 〈0.05 ）, there were no difference in age, tumor volume and the histology type of breast cancers （P 〉 0.05 ）. The consistent rate of C -erbB -2, ER, PR in 43 cases of breast cancer tissue was 51.2%, different rate was 48.8%. The consistent rate of C -erbB -2, p53 in 43 cases of breast cancer tissue was 53.5%, different rate was 46.5%, the expressions of p53, ER, PR were not related with C - erbB - 2 （ P 〉 0.05 ）. Conclusions C - erbB - 2 positive expression is a poor prognosis factor for breast cancer patients. Combined detection of p53, ER and PR may help clinical treatment and prognostic judgement of breast cancer patients.
出处
《中国医师进修杂志》
2007年第6期7-9,共3页
Chinese Journal of Postgraduates of Medicine
