摘要
探讨过度训练大鼠心肌损伤、细胞因子的演变。方法:取健康雄性SD大鼠随机分为正常对照组、一般游泳训练组、过度训练组,分别于运动后即刻和24 h检测血清CK-MB活性、cTnI及TNF-α含量,电镜观察组织形态学变化。结果:过度训练组即刻和24 h血清cTnI、CK-MB及TNF-α均高于正常对照组和一般游泳训练组;过度训练组血清cTnI、血清CK-MB与血清TNF-α均呈正相关;心肌病理组织学和超微结构改变在过度训练组即刻和24 h均明显。结论:长期过度训练存在心肌损伤;肿瘤坏死因子参与了过度训练心肌损伤的发生、发展。
It inquired into the changes of overtrainined rats＇ myocardial injury and cytokine. The method was that male healthy SD rats were randomly divided into a control group （Group C）, a normal swimming group （Group NS） and a overtraining group （Group OT）, measured the activity of serum CK-MB and the contents of cTnⅠ and TNF-α and observed histomorphologic changes by electron microscope immediately and at 24 after exercise separately. The results show that the serum cTnⅠ, CK-MB and TNF-α of Group OT immediately and at 24 after exercise are all higher than those of Group C and Group NS; Both the serum cTnⅠ and CK-MB of Group OT have positive correlation with TNF-α; the myocardial pathohistologic and ultrastructural changes of Group OT immediately and at 24 after exercise are obvious. It concludes that long-term overtraining can cause myocardial injury, while the TNF- Ⅰ partakes the occurrence and development of myocardial injury induced mainly by overtraining. Key words： overtraining; myocardial injury; cTnⅠ; CK-MB; TNF-α
出处
《上海体育学院学报》
CSSCI
北大核心
2007年第5期41-44,50,共5页
Journal of Shanghai University of Sport
基金
国家自然科学基金(30671019)
