摘要
目的比较药物性肝病(DILD)通用诊断标准及Maria评分系统,探讨DILD分级量化诊断的可行性及应用价值。方法分别以通用诊断标准及Maria评分对325例疑诊为DILD的病例进行回顾性诊断及评分,比较评分分值在符合与不符合通用诊断标准的两组之间的分布情况,研究分值与定性诊断之间的关系。结果325例患者中218例符合通用诊断标准,其中208例(95.4%)计分≥10分,107例不符合通用诊断标准,其中79例(73.8%)计分<10分。经ROC分析,Maria标准曲线下面积为0.9121,95%置信区间为(0.8803,0.9439)(Z=25.40,P<0.001)。Maria评分≥10分诊断DILD的敏感性为95.4%,特异性为73.8%。结论两种DILD诊断标准具有较好的一致性,Maria评分系统诊断DILD敏感性高,但特异性较低。
[Objective] To compare Maria clinical scale for the diagnosis of drug-induced liver disease （DILD） with the current criterion and investigate the validation and the value of this scale. [Methods] The information of 325 suspected cases of DILD was scored by Maria scale and diagnosed by current criterion, The relation between the distribution of scores and the diagnosis of these cases was studied and analyzed. [ Results ] There were 218 cases conformed to the criterion, and 208 of them （95.41%）were scored ≥10. There were 107 cases that were not coincident with criterion, and 79 of them were scored 〈10. The area under ROC curve of Maria scale was 0.9121. The 95% confidence interval was （0.8803,0.9439） （Z =25.40,P 〈0.001）. The sensitivity and specificity of Maria score≥10 for diagnosing DILD were 95.41%and 73.83%. [Conclusions] The Maria clinical scale for diagnosing DILD is in correspondence with current criterion. The Maria scale shows good sensitivity and little low specificity and should be improved on basis of actual situation of China.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2007年第17期2157-2159,共3页
China Journal of Modern Medicine
关键词
药物性肝病
诊断
drug-induced liver disease
diagnosis
