摘要
在盐酸介质中，利用磺胺嘧啶-亚硝酸钠-α-萘胺的重氮化-偶合反应，建立了流动注射光度法测定磺胺嘧啶的新方法.利用控制加权形心单纯形优化法选择最佳实验条件，测定的线性范围为0.2-20μg/mL，检出限为0.06μg/mL，进样频率为130次/h.该法已用于药物中磺胺嘧啶含量的测定.
A rapid and sensitive flow-injection spectrophotometric method was proposed for the determination of sulfadiazine. This method is based on the diazotization of sulfadiazine with sodium nitrite in acidic medium and the coupling reaction with α-naphthylamine. The optimal experimental conditions for the flow injection analysis were obtained by using the controlled and weighed centroid simplex method. The linear range of this method is 0.2-20μg/ml. with the detection limit of 0. 06μg/mL, and the sampling frequency is 130 samples per hour. The method was successfully used to determine sulfadiazine in pharmaceuticals.
出处
《周口师范学院学报》
CAS
2007年第5期72-74,共3页
Journal of Zhoukou Normal University
关键词
磺胺嘧啶
流动注射分析
光度法
sulfadiazine
flow injection analysis
spectrophotometry
