摘要
目的:探讨乌司他丁对严重烧伤延迟复苏的作用。方法:18只SD大鼠随机分成假烫组(S组)、烫伤延迟复苏组(B组)和烫伤延迟复苏+乌司他丁组(U组)。U组在烫伤后延迟复苏的同时,于伤后6h、12h分别予乌司他丁20 000 U·kg^(-1)腹腔内注射。伤后24h处死大鼠,测定伤后24h肺、肝干湿重比,测定血清白细胞介素8(IL-8)、肿瘤坏死因子α(TNF-α)、乳酸值和血浆丙二醛含量。结果:B组IL-8、TNF-α、乳酸和丙二醛含量均高于S组,肺、肝干湿重比低于S组(P<0.01),U组大鼠肺、肝干湿重比为0.229 4±s 0.001 2、0.275±0.008,血清IL-8和TNF-α值为(226±16)ng·L^(-1)、(514±24)ng·L^(-1),血清乳酸与血浆丙二醛含量分别为(4.5±0.8)mmol·L^(-1)、(2.52±0.27)nmol·L^(-1),均比B组有明显改善(P<0.05或P<0.01)。结论:乌司他丁可减轻严重烧伤延迟复苏对机体的损伤。
AIM： To explore the effects of ulinastatin on delayed resuscitation of severe bums, METHODS ： Eighteen SD rats were randomly divided into 3 groups： sham group （S group）, bumed and delayed resuscitation group （B group） and therapeutic group （U group） . In U group, ulinastatin （20 000 U·kg^-1） was intraperitoneally injected at 6 h, 12 h after bum with simultaneously prolonged resuscitation. Rats were executed post-bum 24 h and followed by measurement of the ratios for dry weight and wet weight tissues of lungs and livers; together with calculation of the serum contents of interleukin 8 （IL-8） , tumor necrosis factor-alpha （TNF-α）, malondialdehyde （MDA） and lactic acid （LD） . RESULTS： The ratios of dry and wet weight of lung and liver tissues in B group were lower than those in S group, while the levels of IL-8, TNF-α, MDA and LD were higher （P 〈 0.01 ）, respectively. The ratios of dry and wet weight of lung and liver tissues in U group were 0.229 4 ± s 0.001 2 and 0.275 ± 0.008, while levels of IL-8, TNF-α, LD and MDA were （226 ± 16） ng·L^-1, （514 ± 24） ng·L^-1, （4.5 ± 0.8） mmol·L^-1 and （2.52 ± 0.27） nmol·L^-1; all improved much more than those in B group （P 〈 0.05 or P 〈 0.01 ） . CONCLUSION ： Ulinastatin can decrease the injury with delayed resuscitation in severe bums.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2007年第9期675-678,共4页
Chinese Journal of New Drugs and Clinical Remedies
