摘要
目的:以升主动脉缩窄压力超负荷心力衰竭大鼠为研究对象,观察Rho激酶抑制剂法舒地尔对心室重塑和心肌组织Rho家族的小分子鸟苷酸三磷酸酶(Rho GTPases)活性的影响,并探讨两者之间的关系。方法:将雌性心力衰竭Wistar大鼠随机分2组(n=10),法舒地尔(5 mg·kg^(-1))组和模型组,同时制备假手术组;模型组、假手术组用等量生理盐水每日2次腹腔注射。测定治疗4 wk后组织Rho GTPases活性。结果:法舒地尔组左室重量-体重比明显下降(P<0.01),心室重构减轻,心肌组织Rho GTPases活性降低(P<0.01)。结论:Rho激酶抑制剂法舒地尔抑制左室重塑与心肌组织Rho GTPases活性有关。
AIM： To study the relationship between ventricular remodeling and tissue Rho GTPases activity based on observing the effects of Rho kinase inhibitor fasudil in cardiac tissue of pressure overload heart failure model rats. METHODS： Twenty female Wistar rats with heart failure were divided randomly into 2 groups in = 10） ： fasudil group （fasudil 5 mg·kg^-1, bid, ip） and model group （sodium chloride 0.1 mL, bid, ip） . Ten age-matched rats received sham operation were as sham-operation group （sodium chloride 0.1 mL, bid, ip） . After 4-week treatment, Rho GTPases activity was investigated in the three groups. RESULTS： Fasudil contributed to lower the ratio of left ventricular weight to body weight and relieve ventricular remodling （P 〈 0.01 ）, and Rho GTPases activity was lowered in cardiac tissue （P 〈 0.01 ） . CONCLUSION： Fasudil can inhibit tissue remodeling in left ventricle through lowering Rho GTPases activity.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2007年第9期671-674,共4页
Chinese Journal of New Drugs and Clinical Remedies
基金
沈阳市科学技术计划项目(1063317-1-01)
