摘要
目的:观察紫花高乌头总碱对吗啡依赖大鼠CYP2E1代谢活力的影响。方法:采用剂量递增法建立吗啡依赖大鼠模型,注射纳洛酮催促产生戒断症状,高效液相色谱法(HPLC)测定经CYP2E1代谢的探针药物氯唑沙宗血药浓度经时变化。结果:吗啡依赖可致大鼠CYP2E1对探针药物氯唑沙宗的代谢活性增强,催促戒断可致体重减轻,CYP2E1对探针药物氯唑沙宗的代谢活性进一步增强。紫花高乌头总碱可降低大鼠的戒断反应症状分值,控制大鼠的体重下降,下调吗啡依赖所致的CYP2E1的代谢活性增强。结论:紫花高乌头总碱可抑制吗啡依赖大鼠的戒断症状,使吗啡依赖及其催促戒断后增高的CYP2E1代谢活力下调。
Objective ： To study the effect of total alkaloides of aconitum excelsum reichb （AER） on CYP2E1 metabolism activity in morphine dependent rats. Methods：Morphine dependent rat model was induced by administration （im） of morphine at a gradual increasing dosage; withdrawal syndromes were precipitated by naloxone （im）, and CYP2E1 metabolism activity was determined by high performance liquid chromatography（HPLC）. Results ：Morphine withdrawal syndromes of rats were inhibited by AER; body weight loss rats were inhibited to some degree, and CYP2E1 metabolism activity th heightened by morphine withdrawal was depressed. Conclusion：AER can inhibit morphine syndromes and down regulate CYP2E1 metabolism activity heightened by withdrawal.
出处
《中国药物依赖性杂志》
CAS
CSCD
2007年第4期262-265,共4页
Chinese Journal of Drug Dependence
关键词
紫花高乌头总碱
吗啡依赖大鼠
戒断症状
total alkaloides of aconitum excelsum reichb
morphine dependent rat syndrome at had been - withdrawal
withdrawal
