摘要
目的探讨缬沙坦对兔动脉粥样硬化管壁及相关基因的研究。方法将白兔随机分成对照组.胆固醇组和不同剂量缬沙坦加胆固醇组。建立家兔动脉粥样硬化模型,观察各组家兔 c-myc、c-fos 变化及大动脉管壁、管腔和粥样斑变化。结果 (1)病理学上,高剂量组的主动脉斑块面积比明显降低(P<0.05).低剂量组与胆固醇组比较差异无统计学意义。(2)胆固醇组的动脉粥样硬化相关基因 c-mys、c-fos mRNA 表达的阳性率较对照组显著增高,而高剂量组的阳性率则显著低于胆固醇组(P<0.05),中、低剂量组与胆固醇组比较差异无统计学意义。结论大剂量的缬沙坦能有效防止兔动脉粥样硬化形成和发展。
Objective To investigate the effect of different doses valsartan on atherosclerosis in rabbits. Methods 53 white rabbits were randomly divided into control group, cholesterol group, and valsartan group of high-, middle-, and low-dose. The positive expression of pro-oncogene c-myc and c-fos mRNA was studied with in situ reverse transcription-PCR （ISRT-PCR）. The histoppathological changes of aorta were observed. Results （1） Positive expression rate of pro-oncogene c-myc and c-fos mRNA was significantly higher in cholesterol than that in the control group. The rate of positive expression was remarkably lower in the high-dose valsartan group than that in the cholesterol group（P 〈0.05）. No significant difference was observed between valsartan groups in middle-/low dose and the cholesterol group. Conclusion h is suggested that relatively higher doses of valsartan can prevent atherosclerotic development and protect the formation of aorta plague.
出处
《中国基层医药》
CAS
2007年第7期1084-1085,共2页
Chinese Journal of Primary Medicine and Pharmacy
