摘要
为了探讨体液免疫反应在高原肺水肿（HAPE）的发病机理中是否起作用，我们用单项免疫扩散定量测定法对49例患者血清及其中8例的肺泡灌洗液中免疫球蛋白（IgG、IgA、IgM）与补作（C3、C4、C5、C9）含量进行测定，并用荧光比色法测定其中8例的血浆与肺泡灌洗液中组胺与5—羟色胺（5－HT）含量。结果：HAPE患者血清与肺泡灌洗液中IgG，IgM,C3，C4，以及血浆与肺泡灌洗液中组胺含量均显著增高（P＜0．01），C5、C9增高（P＜0．05），治愈后，血液中上述物质均降至对照组水平（P＞0．05），肺泡灌洗液未复查。提示：体液免疫反应在HAPE的发病机理中有非常重要的作用。鉴于HAPE在体液免疫反应参与下的发病机理与Ⅲ型超敏反应的发病机理相同，我们认为，HAPE可能为超敏反应Ⅲ型疾病的肺部表现，但尚须深入研究确定。
In order to researeh the role of humoral immune reaction in the pathogenesis of high altitude pulmonary edema (HAPE). We had measured immunoglobin,including IgA, IgG,IgM and complements,including C3,C4,C5,C9 in serum for 49 patients with HAPE,and in lung lavage fluid for 8 patients of them by quantitative immunodiffusion. In addition, histamine and 5 - hydroxytryptamine (5-HT)were measured for 8 of 49 patients in plasma and lung lavage fluid by fluorocolorimetry. Based on these data,it was suggested that the humoral immune reaction played an important role in the pathogehesis of HAPE. IgG, IgM,C3,C4 in serum and lung lavage fluid, histamine in plasma and lung lavage fluid were increased obviously(P<0. 01 ), C5,C9 increased too (P<0. 05). By rescue,above substances were reduced to levels of control group (P<0.05), but same substances in lung lavage fluid were not re-examined. In view of similarity that was appeared between the pathogenesis of HAPE caused by humoral immune reaction and the pathogenesis of supersonsitive reactionⅢ type,we consider that the HAPE,may be resulted from humoral immune reaction due to hypoxia,therefore HAPE may be a pulmonary manifestation of supersensitive reaction Ⅲ type.
出处
《高原医学杂志》
CAS
1997年第1期9-12,共4页
Journal of High Altitude Medicine
基金
军队"八五"指令性攻关资助
关键词
体液免疫反应
高原性
肺水肿
病理
Humoral immune reaction
Altitude
Pulmonary edema
Pathogenesis
