摘要
通过对34名平原人乘飞机进驻海拔4370m 高原后尿蛋白的动态分析和急性高原病(AMS)的调查,我们看到,受试者在达高原的1～3天内尿蛋白阳性率为20.6～26.5%,尿潜血反应阳性率为5.9～14.8%,4天后均接近平原值;AMS 者的尿蛋白浓度明显高于未患AMS 者(28.9±4.4v.s.17.1±2.2,p<0.05);在AMS 患者中,69.2%的人(9/13)尿蛋白阳性,30.8%的人(4/13)尿蛋白可疑,而且尿蛋白阳性者的AMS 症状持续的时间明显长于非尿蛋白阳性者(4.4±0.1v.s.3.6±0.1,p<0.05)。上述结果提示,平原人在快速进驻高原初期肾功能会受到严重影响,但经短期高原适应后是可以很快恢复的;AMS 与高原性蛋白尿有密切的关系;蛋白尿的产生可能是由肾小球基底膜受损后通透增加所致。
Thirty four unacclimatized healthy men were flown to 3700m in 2 hoursand then driven to 4370m in 24 hours and stayed at 4370m for 6 days.Early-morningurine specimens were collected at the altitude of 4370m.1+proteinuria appeared in 20.6～26.5% of subjects and 1+occult blood reaction appeared in 5.9～14.8% of subjects fromthe Ist to the 3rd day,and then dropped gradually to normal level after the 4th day.Con-centration of proteinuria in subjects with acute mountain sickness(AMS)was 1.7 times asmuch as that of the subjects without AMS(P<0. 05).69.2%(9/13)of the individualswith AMS had 1+proteinuria and 30. 8%(4/13)of those without AMS had 1+protein-uria,and the clinical features of the subjects with 1+proteinuria lasted for a longer timethan those with+-proteinuria(4.4 days V.S.3.6 days;P<0. 05).The results impli-eated that there was severe damage to kidneys in the early days of rapid exposure to high al-titude and the proteinuria was closely related to AMS.The increase of glomerular permeabil-ity to protein might be one of the main factors of the mechanism for altitude proteinuria.
出处
《航天医学与医学工程》
CAS
CSCD
1993年第1期69-72,共4页
Space Medicine & Medical Engineering
