摘要
目的:研究胃癌组织中bcl-2和bax的表达及其意义,探讨二者在胃癌中表达的相关性。方法:采用SP免疫组化法观察50例胃癌组织和20例慢性浅表性胃炎石蜡标本中bcl-2蛋白和bax蛋白的表达情况。结果:胃癌组织中bcl-2蛋白的阳性表达率(60%)明显高于慢性浅表性胃炎(30%)(P<0.05),bax蛋白的阳性表达率(40%)明显低于慢性浅表性胃炎(80%)(P<0.05);胃癌中bcl-2和bax的表达之间呈明显的相关性(P<0.05)。结论:bcl-2和bax协同作用参与了胃癌的发生发展。
Objective：To investigate the expression of bcl-2, bax and their relationships in human gastric cancer（GC）.Methods：SP immunohistochemistry was used to detect the expression of bcl-2 and bax in 80 GC and 20 chronic superficial gastritis （CSG） paraffin-embedded specimens.Results：In GC,the positive rate of bcl-2 protein was 60%,which was obviously higher than that in CSG（P〈0.05）;the positive rate of bax protein was 40%,which was obviously lower than CSG（P〈0.05）.There had significant relationships between the expression of bcl-2 and bax protein in GC（P〈0.05）.Condusions：Bcl-2 and bax have synergistic effects in the development of GC.
出处
《承德医学院学报》
2007年第3期231-232,共2页
Journal of Chengde Medical University
关键词
胃癌
免疫组化
BCL-2
BAX
Gastric cancer （GC）
Immunohistochemistry
Bcl-2
Bax
