摘要
目的探讨儿童哮喘急性发作期血浆D-二聚体变化及临床意义。方法对45例哮喘患儿急性发作期与缓解后第三天及21例健康对照组儿童采用胶乳凝集半定量方法检测血浆D-二聚体,同时监测肺通气功能FEV1占预计值%。结果哮喘患儿急性发作期血浆D-二聚体水平明显增高,此期FEV1占预计值%显著下降,哮喘缓解后D-二聚体值下降,FEV1占预计值%增加。结论儿童哮喘急性发作期体内存在高凝状态,血浆D-二聚体水平变化可作为判断病情及观察治疗效果的指标之一。
Objective To investigate the change in plasma D-dimer levels during an asthmatic acute onset and its clinical significance in children. Methods The plasma D-dimer levels were detected by semiquantitative latex agglutination method in 45 children with asthma during acute onset and 3 days after remission of asthma and in 21 healthy control children. The ratio of pulmonary ventilation function of forced expiratory volume（FEV1 ） to predicted value（PV） were simultaneously monitored. Results The plasma D-dimer levels in asthma children significantly increased and the ratio of FEV1 to PV significantly decreased during an asthmatic acute onset. The plasma D-dimer levels decreased and the ratio of FEV1 to PV increased after the remission of asthma. Conclusion There is the hypercoagulable state in the children with acute onset of asthma. The change in plasma D-dimer levels might be a marker reflecting the severity of asthma and therapeutic effect.
出处
《华南国防医学杂志》
CAS
2007年第4期8-9,共2页
Military Medical Journal of South China
