摘要
目前国内外针对共济失调毛细血管扩张症的致病基因ATM基因的研究不断增多，自从Swift等第一次报道了ATM杂合子患乳腺癌的风险增加后，作为乳腺癌危险因子ATM基因受到国内外学者的关注。ATM基因位于人类染色体的11q22-q23，其蛋白主要参与DNA的损伤识别和修复、细胞周期的调控。ATM基因作为抑癌基因在乳腺癌的发生发展中起重要的作用。可把研究ATM基因与ATM杂合子的乳腺癌患病风险的关系作为研究ATM与肿瘤发生发展关系的切人点，并最终为肿瘤的预防和治疗带来新的理论与方法。该文对ATM基因结构、功能、增加癌症易感性的机制及其与乳腺癌患病风险的关系作一概述。
The research on Ataxia-telangiectasia （ATM） mutated gene is increasingly conducted. Since Swift and his colleagues first reported that ATM heterozygotes in AT families had higher risk of suffering breast cancer, many researchers are paying close attention to ATM as a risk factor for breast cancer. Locating in the human chromosome 11q22-q23, this gene is referred to the repair of DNA damage and the regulation of cell cycle check-point. As an anti-oncogene, ATM plays important roles in the carcinogenesis of breast cancer. We can take the relationship between ATM and the risks of developing breast cancer of ATM heterozygotes as the entrance of study of carcinogenesis, then find out new theories and method for prevention and therapy of tumors. This article reviews the structure and functions of the ATM, how it increases the cancer susceptibility and the relationship between ATM and the risks of developing breast cancer.
出处
《国际遗传学杂志》
CAS
2007年第4期282-286,共5页
International Journal of Genetics
