摘要
目的:探讨survivin mRNA在肝细胞肝癌(HCC)及癌旁组织的表达及意义。方法:用逆转录聚合酶链反应测定32例HCC癌组织及癌旁组织中survivin mRNA的表达。结果:Survivin mRNA在HCC组织中高度表达,阳性率为65.6%,癌旁组织中未见表达,Survivin mRNA的表达与HCC门静脉癌栓发生密切相关(P<0.05),而与其它指标无明显差异。结论:Survivin mRNA高表达可以作为判断HCC侵袭性和进展的一个潜在重要指标。
Objective :To investigate the expressions and significance of survivin mRNA in hepatocellular carcinoma(HCC) tissues. Methods: RT- PCR was used to detect the expression of survivin mRNA in samples of HCC tissue from 32 patients. Results: The expression of survivin mRNA in the HCC tissues was significantly higher,expression rate was 65.6% ,no expression was detectable in paratumor tissue. There was significant correlation between the expression of survivin mRNA in HCC and the tumor thrombus in portal vein(P 〈0.05). Conclusion: The survivin mRNA high expression is of potential value in judging invasion and progression of HCC.
出处
《现代肿瘤医学》
CAS
2007年第8期1137-1138,共2页
Journal of Modern Oncology