摘要
以丙烯酸酯压敏胶为基质制备冠心膏贴片。通过测定贴片的180°剥离强度和持黏力优化贴片组方,并测定了贴片中丹参酮ⅡA含量以及贴片的体外释放行为。结果表明,贴片的优化组方为:水0.24～0.30g,乙醇0.18～0.24g,丙烯酸树脂0.15g。按优化组方制得的贴片12h体外释放度24.6%,高于市售冠心膏贴剂。
The Guanxingao patch was prepared by acrylic pressure sensitive adhesive as matrix. The formulation was optimized by orthogonal test using 180° peel strength and hold adhesion as parameters. The content of tanshinone Ⅱ A in the patch and its in vitro release were examined. The results showed that the optimized formulation was as follows： water 0.24 - 0.30g, ethanol 0.18 - 0.24g and acrylicresin 0.15g. The 12h accumulative release of tanshinone Ⅱ A of the preparation was 24.6 %, which showed higher than that of patches in market.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2007年第8期561-563,共3页
Chinese Journal of Pharmaceuticals
关键词
冠心膏贴片
丙烯酸酯压敏胶
丹参酮ⅡA
Guanxingao patch
acrylic pressure sensitive adhesive
tanshinone Ⅱ A
