摘要
目的:分析间质性肺疾病(ILD)的HRCT表现及与普通病理学和免疫病理学表现的关系。方法:19例经手术病理证实的肺间质纤维化病人和7例正常对照分别行HRCT扫描,组织病理学检查(包括HE、Masson氏三色染色)及免疫组化,分析其HRCT表现及相关病理学表现的关系。结果:ILD的HRCT基本征象及分期有其相应镜下病理表现,bFGF、TGF-β1、TNF-α与肺小叶间隔增粗、肺内渗出毛玻璃影、小叶核增粗、肺内异常线影及肺内小结节等HRCT征象中有较强的相关性。结论:HRCT是一种安全、有效、无创性的诊断ILD的手段,肺小叶间隔增粗、肺内渗出毛玻璃影、小叶核增粗、肺内异常线影及肺内小结节是间质性肺疾病较为可靠的HRCT征象。
Objective： The purpose o this study is to analyse the HRCT appearance of interstitial lung disease and the relations with pathology and immunohistochemistry.Methods： 19 eases ILD patients proved pathologically and 7 eases control were performed with HRCT acan and histologic examinations. HRCT images were analysed. Histologic examinations including HE staining,Masson trichrome staining and immunohistochemistry . Results： HRCT appearances and different stages of ILD corresponded with pathological findings. There were strong relations between bFGF.TGF-β1. TNF-α and septal thickening, ground glass opacity, abnormal lines, small nodules. Conclusion：For ILD,HRCT is a safe,effective and undamaged diagnosis means. Septal thickening, ground glass opacity, abnormal lines, small nodules are reliable HRCT signs of ILD.
出处
《医学影像学杂志》
2007年第7期683-686,共4页
Journal of Medical Imaging
关键词
间质性肺疾病
体层摄影术
X线计算机
病理学
免疫组织化学
Interstitial lung disease
High-resolutlon Computed tomography
Pathology, immunohistochemisry
