摘要
本研究旨在验证大剂量叶酸（10mg／d）对急性心肌梗死（AMI）后行冠状动脉介入的患者内皮功能的影响，并确定其与同型半胱氨酸水平的关系。测定40例AMI后患者[16例患者同型半胱氨酸水平正常，24例患者同型半胱氨酸水平升高（〉11μmol／L）]肱动脉的血流介导舒张功能（FMD）。在此双盲、交叉对照临床试验中，受试者被随机分配首先接受叶酸（10mg／d，A组）或安慰剂（B组）服用6周，经2周的洗脱期后交叉。评估基线、6周和14周时的血浆叶酸盐、总同型半胱氨酸及其亚型（氧化型、还原型和蛋白结合型）的水平、FMD和硝酸甘油介导的血管舒张。在A组中，叶酸使FMD从3．98％±0．35％增至6．44％±0．56％（P〈0．001）；
The aim of this study was to test the influence of high-dose folic acid（10 mg/d） on endothelial function in patients referred for coronary intervention after an acute myocardial infarction（AMI） and determine its relation to homocysteine levels. Flow-mediated dilation（FMD） of the brachial artery was performed in 40 patients after AMI（16 with normal homocysteine levels and 24 patients with elevated levels [〉 ll Ixmol/L]） . Subjects were randomized to receive first folic acid（ 10 mg/day; group A） or placebo（group B） for 6 weeks in a double-blind crossover trial with a 2-week washout. Plasma folate, total homocysteine and its subtypes（oxidized, reduced, and protein-bound）, FMD, and nitroglycerin-mediated dilation were assessed at baseline and at 6 and 14 weeks.
