摘要
高血压是我国人群脑卒中及冠心病发病的首位危险因素,严重危害人群健康。目前,我国高血压患者已超过2.7亿,并以每年1 000万人的速度递增,如何提高对高血压的预防和治疗水平已成为迫切需要解决的重大医学和社会问题。以往对于高血压的研究主要集中于外周。近来研究表明,中枢调控在高血压的发生发展中具有重要作用。其中下丘脑室旁核(hypothalamic paraventricular nucleus,PVN)在维持心血管活动中起着关键作用,可直接支配交感神经节前神经元,参与外周交感神经活动的调节,并与高血压的发生发展密切相关。近年来研究表明,室旁核中炎性细胞因子(proinflammatory cytokines,PIC)、活性氧簇(reactive oxygen species,ROS)、肾素-血管紧张素系统(reninangiotensin system,RAS)、神经递质(neurotransmitter,NT)及核因子κB(nuclear factorκB,NF-κB)等神经激素参与高血压的病理生理过程,但室旁核中这些神经激素如何激活、相互间的作用以及对高血压的调控机制尚不清楚。因此,探明下丘脑室旁核神经激素兴奋对高血压的影响是本课题的研究重点。本研究将为高血压的中枢机制研究补充新内容。
Hypertension, the first risk factor for stroke and coronary heart disease in the seriously endangers people＇s health. At present, China has more than 270 million people with annual increase rate of 10 million people. Then how to improve prevention and treatment become an urgent need to solve major medical and social problems. In the past, research on Chinese population, hypertension and an of hypertension has hypertension mainly focused on the peripheral area. while recent research has shown that the central regulation plays an important role in the development of hypertension, llypothalamic paravcntricular nucleus （PVN）. which plays a key role in maintaining cardiovascular activity, can directly control the sympathetic preganglionic neurons and regulate peripheral sympathetic nerve activity, tht, s being closely related to the development of hypertension. Research in recent years shows that the comprehensive effects of proinflammatory cytokines （PIC）. reactive oxygen species （ROS） rcnin-angiotcnsin system （RAS）. ncurotransmittcr （Nq＇） and nuclear factor kB （NF-kB） are involved in the pathogcncsis of hypertension. However. it is unclcar how these ncurohormoncs in I＇VN are activated, how they interact with each other and what role they play in the regulatory mechanism of hypertension. Therefore, the key focus of this research is tocxplore the impact of activated neurohormoncsin PVN on hypertension. This study will provide new content for the study on hypertension.
出处
《西安交通大学学报（医学版）》
CAS
CSCD
北大核心
2017年第1期1-6,共6页
Journal of Xi’an Jiaotong University（Medical Sciences）
基金
国家自然科学基金重大研究计划项目(No.91439120)
国家自然科学基金面上项目(No.81370356
81170248
81070199)~~
