摘要
目的探讨冠心病(CHD)患者幽门螺杆菌(Hp)感染与C反应蛋白(CRP)、血脂的相互关系,探讨其可能的发病机制。方法对2004年3月至2005年1月深圳市罗湖区人民医院心内科收治的70例CHD患者,按临床诊断分为2组,采用酶联免疫吸附试验(ELISA)法检测急性心肌梗死(AMI)组、心绞痛(AP)组及对照组患者各35例外周血Hp抗体(HpIgG),同时测定血脂及CRP。结果AMI组、AP组及对照组血清HpIgG抗体阳性率分别为54.3%、45.7%及25.7%,AMI组、AP组分别与对照组比较差异有统计学意义(P<0.05),但AMI组与AP组间比较差异无统计学意义;血清CRP及血脂总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A(apoA)AMI组、AP组显著高于对照组(P<0.01),而高密度脂蛋白胆固醇(HDL-C)AMI组、AP组显著低于对照组(P<0.01),AMI组也明显低于AP组(P<0.01);Hp感染者HpIgG水平与血中CRP、TG、LDL-C及apoA有明显相关性(r分别为0.44、0.64、0.36和0.32),而与HDL-C成负相关(r=-0.78)(P<0.01)。结论CHD患者Hp感染率明显增高,Hp可能通过炎症反应及影响脂质代谢在CHD的发生、发展中起作用。
Objective To investigate the relationship between helicobacter pylori （Hp） infection and serum lipid or C - reactive protein （CRP） levels in patients with coronary heart disease （CHD）. Methods Serum specific antibodies to Hp （ Hp IgG ）, serum lipid and CRP were measured in healthy subjects （ control group, n = 35 ） and patients with CHD, including patients with acute myocardial infarction （ AMI group, n = 35 ） and angina pectoris （ AP group, n = 35 ）. Results The positive rate of Hp IgG was 54.3 % in AMI group, 45.7 % in AP group and 25. 7% in control group, The positive rate of Hp IgG was significantly higher in patients with AMI or AP than in control group （ P 〈 0.05 ）. Serum CRP, total cholesterol （TC）, triglycerides （TG）, low density lipoprotein cholesterol （LDL -C ） , apolipoprotein A （apo A ） were significantly higher in patients with CHD than in control group （ all P 〈 0.01 ）, while high density lipoprotein cholesterol （ HDL - C） was significantly lower iu patients with CHD than in control group（ P 〈0.01 ）, HDL - C was significantly lower in patients with AMI than in patients with AP （ P 〈0.01 ）. Hp IgG was positively correlated with CRP, TG, LDL - C and apo A （ r = 0.44, 0. 64, 0. 36 and. 32, respectively） but negatively correlated with HDL - C in patients with CHD （ r = - 0.78, P 〈 0.01 ）. Conclusion Hp infection rate is significantly higher in patients with CHD. Hp infection may play a role in the pathogenesis of CHD through inflammatory reaction and lipid metabolic disturbance.
出处
《临床和实验医学杂志》
2007年第8期18-19,共2页
Journal of Clinical and Experimental Medicine
关键词
幽门螺杆菌
冠状动脉疾病
C反应蛋白
高脂血症
Helicobacter pylori
Coronary heart disease
C - reactive protein
Hyperlipidemia
