摘要
为了观察艾素(多西他赛,DOC)联合奥沙利铂(L-OHP)治疗晚期结直肠癌的疗效和毒副反应,对34例晚期结直肠癌患者采用DOC联合L-OHP方案化疗,DOC75mg/m2,静脉滴入,d1;L-OHP130mg/m2,静脉滴入,d2;28d为1个周期,至少2个周期后评定疗效。结果示34例可评价疗效,其中完全缓解(CR)1例,部分缓解(PR)12例,总有效率(CR+PR)为38.2%。中位生存期12个月。毒副反应主要为骨髓抑制、周围神经炎和脱发。初步研究结果提示,DOC联合L-OHP方案治疗晚期结直肠癌,缓解率高,毒副反应可以耐受。
In order to evaluate the efficacy and toxicity of docetaxel（DOC） combined with oxaliplatin （L-OHP） in the treatment of patients with advanced colorectal cancer, thirty-four cases with advanced colorectal cancern were treated by DOC combined with L-OHP： DOC 75mg/m^2 , iv gtt, at Day 1; L-OHP 130 mg/m^2, iv gtt, at Day 2. Each cycle included 28 days. After continuous two cycles, 27 out of 34 cases could be evaluated, 1 obtained complete response （CR） and 12 partial re-sponse （PR） with a total response rate of 38.2o,%o. The median survival duration was 12 months. The major toxicities were myelosuppression, peripheral neuritis and alopecia. In conclusion, the regimen of DOC combined with L-OHP in the treatment of patients with advanced colorectal cancer produces high response rate and its toxicity is well tolerable.
出处
《中华肿瘤防治杂志》
CAS
2007年第15期1182-1183,共2页
Chinese Journal of Cancer Prevention and Treatment
