摘要
目的:观察多西紫杉醇(多西他赛)为主方案治疗晚期上消化道癌的客观疗效和毒副反应。方法:全组31例患者,其中食管癌9例,贲门癌5例,胃癌17例,均为复治患者。应用TP(多西他赛30mg/m2,静脉滴入,d1、d8、d15;顺铂20mg/d,静脉滴入,d1～d5)或TF方案(多西他赛30mg/m2,静脉滴入,d1、d8、d15;5氟尿嘧啶500mg/m2,静脉滴入,d1～d5),每28d重复,每例患者接受2个周期以上方可评价疗效。结果:31例患者均可评价疗效和毒副反应,PR8例,NC13例,PD10例,有效率为25.8%(8/31),疾病控制率为67.7%(21/31),中位TTP为4.9个月。主要毒副反应为骨髓抑制和乏力。结论:多西他赛为主方案治疗晚期上消化道癌患者疗效较好,毒副反应可以耐受,值得进一步观察。
OBJECTIVE：To evaluate the efficacy and toxicity of doeetaxel based regimen in the treatment of advanced upper di gestive tract carcinoma. METHODS：Thirty-one patients were trea ted with TF regimen or TP regimen. They were also previously treated, doeetaxel was given with weekly procedure, docetaxel 30 mg/m^2 i.v. on d1 ,d8 ,d15, 5-Flurouracil 500 mg/m^2 , i. v, d1 -d5 or DDP 20 mg/d, i. v, d1 - d5. The cycles repeated for every 28 days. All the patients received over two cycles of chemotherapy. RESULTS.All patients were evaluable for response and toxicity. There were 8 patients with PR and 13 patients with SD. The overall response rate and the disease control rate were 25.8% （8/31） and 67.7%（21/31） respectively. The median time of tumor progression was 4.9 months. The major toxicities were bone suppression and fatigue. CONCLUSIONS.. Docetaxel combinated with other chemotherapeutic agents are effective in the treatment of advanced upper digest tract carcinoma patients who are treated previously, and the toxicity is tolerable. It is worth observing further in the future.
出处
《肿瘤防治杂志》
2005年第23期1809-1811,共3页
China Journal of Cancer Prevention and Treatment
关键词
消化系统肿瘤/药物疗法
紫杉酚/授药和剂量
疗效
digestive system neoplasms/ drug therapy
paelitaxel/administration ＆ dosage
efficacy
