摘要
目的:采用半固体骨架技术提高黄豆苷元的体外溶出度。方法:采用熔融法制备黄豆苷元半固体骨架胶囊,比较不同载体材料聚氧乙烯(40)硬脂酸酯(S-40)、泊洛沙姆、聚乙二醇(PEG)4000,不同含药量(2%、4%、6%),表面活性剂吐温-80不同用量(15%、20%、25%、30%)对其体外溶出度的影响并与市售胶囊进行比较。结果:上述3种影响因素中溶出度较优的选择为采用S-40为载体,含药量为2%,吐温-80用量20%。所制胶囊体外溶出速率快于市售胶囊。结论:半固体骨架技术能够提高难溶性药物黄豆苷元的体外溶出度。
OBJECTIVE： To enhance the dissolution of daidzein by semisolid matrix technique. METHODS ： Semi - solid matrix capsules were prepared by fusion method. The influences of different carriers including polyoxyethylene （40）, stearate （S- 40）, poloxamer, and polyethylene glycol （PEG） 4000, drug contents （2%, 4%, and 6%）, contents of surfactants- tween 80 （15%, 20%, 25%, and 30% ） on the dissolution in vitro were analyzed and which were compared with the common capsules sold in the market. RESULTS： Optimal dissolution was obtained when the condition of the above three factors was as follows： the carrier was S- 40; the drug content = 2%, and the content of twieen- 80 ： 20%. The dissolution rate of the capsule prepared in this condition was higher than that of the common capsule. CONCLUSION： The in vitro dissolution rate of daidzein （which is hard to dissolve） could be enhanced by semi- solid matrix technique.
出处
《中国药房》
CAS
CSCD
北大核心
2007年第22期1716-1718,共3页
China Pharmacy
