摘要
目的探讨宫内发育迟缓(IUGR)儿出生后脐血胰岛素样生长因子-1(IGF-1)、胰岛素样生长因子结合蛋白3(IGFBP3)、胰岛素(Ins)及瘦素(Lep)的变化。方法选择141例IUGR儿为IUGR组,以同期出生的足月、适于胎龄儿30例作为对照组,比较两组出生后脐血IGF-1、IGFBP3、Ins和Lep的浓度。结果IUGR组IGF-1、IGFBP3、Ins和Lep的浓度均明显低于对照组(P值分别＜0．01、0．05)。IUGR组IGF-1与IGFBP3(r= 0．6434)和Ins(r=0．4367)、Ins与Lep(r=0．3461)均呈正相关(P值均＜0．01),IGF-1与Lep、IGFBP3与Ins和Lep均不相关(P值均＞0．05)。结论IGF-1、IGFBP3、Ins及Lep低下是导致IUGR的原因, Ins-IGF-1-IGFBP3及Ins-Lep轴各自调控胎儿的生长发育。
Objective To investigate the change of serum levels of insulin-like growth factor 1 （IGF-I）, insulin-like growth factor-binding protein-3 （IGFBP3）, leptin and insulin levels in intrauterine growth retardation （IUGR）. Methods Levels of serum IGF-I, IGFBP3, Leptin and insulin in the cord blood were measured in 141 IUGR and 30 normal newborns. Results Levels of serum IGF-I, leptin of IUGR were significantly lower than those of normal newborns （P 〈 0.01） ; the levels of IGFBP3, insulin of IUGR were also significantly lower than those of the normal newborns （P 〈 0.05）. Serum. IGF-I was significantly correlated with IGF-BP3 and insulin levels （P 〈 0.05）, but not with [eptin （P 〉 0.05）. IGF-BP3 level was not correlated with Leptin and insulin level （P 〉 0.05）. Insulin had significant relevance with leptin （P 〈 0.05）. Conclusion The low serum levels of insulin, IGF-I, IGFBP3 and leptin can result in development of IUGR. Insulin-IGF-I-IGFBP3 and insulin-leptin controls the growth and development of the fetus. （Shanghai Med J, 2007, 30：425-427）
出处
《上海医学》
CAS
CSCD
北大核心
2007年第6期425-427,共3页
Shanghai Medical Journal
基金
上海市科委科研基金(034119812)
