摘要
目的:初步探讨不同治则代表方药对人胃癌BGC细胞株细胞凋亡和端粒酶活性的影响。方法:不同治则代表方药含药血清作用于BGC细胞48 h,以流式细胞术检测细胞凋亡率及端粒酶活性。结果:各含药血清作用于BGC细胞48 h后,凋亡率均有不同程度增加、端粒酶活性均有不同程度降低。但凋亡率、端粒酶活性与含药血清浓度不完全成正比。结论:促进BGC细胞凋亡并抑制端粒酶活性,可能是不同治则代表方药抑制BGC细胞增殖的共同作用机制之一。
Objective：To investigate the mechanism of inhibiting effect of Chinese medicine on gastric cancer BGC cell in vitro. Methods：BGC cells treateded by Chinese medieine containing serum for 48 h. Flow eytometer methods were used to investigate the apoptosis rate and telomerase activity of BGC cells. Results： The Chinese medicine could promote the apoptosis and inhibit the telomerase activity of BGC cells. Conclusions：The present results showed that inhibiting proliferation, promoting apoptosis and inhibiting telomerase activity of BGC cells are some of the mechanisms of the anti-cancer effect of Chinese medicine.
出处
《山东中医药大学学报》
2007年第4期329-331,345,共4页
Journal of Shandong University of Traditional Chinese Medicine
基金
山东省优秀中青年科学家科研奖励基金(编号:02BS090)
