摘要
观察了静脉注入肿瘤细胞前24h，75mGyX射线全身照射对小鼠免疫功能的影响。结果表明照射组小鼠胸腺S期细胞百分数于照射后4d，胸腺CD3+细胞百分数于照射后2、8d，脾细胞IL－2和γIFN分泌于照射后4d，脾脏NK细胞活性于照射后2、4、6和8d均较假照射组明显增高（P＜0．05～0．01）。提示小剂量辐射增强机体免疫功能可能与其抑制肿瘤细胞播散有关。
In this paper, influence of low dose radiation on immunity in C 57 BL/6 mice injected with cancer cells was studied. In mice given 75 mGy WBI 24 h before injection of Lewis lung carcinoma cells or B16 melonoma cells,the percentage of S-phase thymocytes and CD3+ thymocytes, the splenic NK cell activity, IL-2 secretion and γIFN secretion were found to be potentiated 2~8 day after irradiation in comparision with the sham-irradiation mice. The results suggest that low dose radiation might suppress cancer cell dissemination via the enhancement of immune reactivity.
出处
《辐射研究与辐射工艺学报》
EI
CAS
CSCD
北大核心
1997年第1期40-43,共4页
Journal of Radiation Research and Radiation Processing
基金
国家自然科学基金
关键词
小剂量辐射
肿瘤细胞播散
NK细胞活性
免疫
Low dose radiation, Tumor cell dissemination, NK cell activity,IL-2 secretion, γIFN secretion
