摘要
小鼠受５０，７５，１００和１５０ｍＧｙＸ射线全身照射后２４小时经球后静脉注入Ｌｅｗｉｓ肺癌或Ｂ１６黑色素瘤细胞。注后１４天以计数肺肿瘤结节数为指标，发现受照小鼠癌细胞播散明显低于假照射对照小鼠。Ｌｅｗｉｓ肺癌细胞注入前２４小时接受７５ｍＧｙ全身照射小鼠与注入相同癌细胞数的假照射小鼠比较，发现照后２～６天脾脏ＮＫ细胞活性和ＩＬ－２分泌均增高。提示低剂量辐射可能通过增强免疫反应抑制癌细胞播散。
Lewis lung carcinoma or B_(16)melanoma cells were injected into the retrobulbar vein of mice 24h after whole-body irradiation (WBI) with 50, 75 , 100 or 150 mGy X-rays. The dissemination of the cancer cells as evaluated by counting the tumor nodules on the lung surface 14d after injection was found to be markedly decreased in the irradiated rnice as compared with the sham-irradiated control. In mice given 75 mGy WBI 24h before injection of Lewis lung carcinoma cells the splenic NK cell activity and IL-2 secretion were found to be potentiated 2-6 days after irradiation in comparison with the sham-irradiated mice which received the same number of tumor cells. The results suggest that low dose radiation might suppress cancer cell dissemination via the enhancement of immune rcactivity.
出处
《中华放射医学与防护杂志》
CAS
CSCD
北大核心
1996年第5期307-309,共3页
Chinese Journal of Radiological Medicine and Protection
基金
国家自然科学基金
