摘要
目的:研究气道平滑肌细胞钾通道功能状态在哮喘患者气道高反应性形成中的作用，探讨钾通道激活剂在哮喘防治中的意义。方法:以随机单盲交叉安慰剂对照法测定12例缓解期哮喘患者和10例正常人在吸入钾通道激活剂Lemakalim后对乙酰甲胆碱的气道反应性。结果：缓解期哮喘患者的气道起始阻力（Rrs）和气道敏感性（以最低累积反应剂量Dmin表示）明显高于正常人，分别为（0．72±0．05）和（0．41±0．01）kPa·L1·s(-1)；（0．34±0．12）和（1．92±0．03）mg；单剂量吸入Lemakalim37．5μg，哮喘患者的气道阻力和敏感性均明显降低，分别为（0．55±0．02）kPa·L(-1)·s(-1)和（3．16±0．81）mg。结果：哮喘患者的气道平滑肌细胞钾通道功能受阻，并参与气道高反应性形成；钾通道激活剂可用于哮喘的预防和治疗。
To investigate the functional state of potassium channel in airway smooth muscle inbronchial hyperresponsiveness (BHR) and review the significance of potassium channel activators in treat-ment of asthma. Methods: Randomised, single blind, placebo controlled, crossover method was used tomeasure airway reactivity to methycholine(Mch) in 12 asthmatics and 10 healthy people. Results: The ex-periment showed that the initial airway resistance(Rrs) and sensitivity (expressed as a minimum amountof cumulative o8se, Dmin)to Mch were significantly higher in asthmatics than that in healthy people (0. 72±0. 05) vs (0. 41±0. 01)kPa. L-1. s-1 in Rrs (P<0. 01), and (0. 34±0. 12) vs (1. 92±0. 03)mg in Dmin(P < 0. 01 ), respectively. lnhaling single dose of Lemakalim (37. 5 pg) reduced Rrs and increased Dminmarkedly in asthmatics (0. 72 ±0. 05) vs(0. 55±0.02)kPa. L-1. s-1 (P<0. 05) l and (0. 34±0 . 12) vs(3. 16 ± 0. 81 )mg (P<0. 01 ),respectively. Copnclusion: (1 ) There may be blockade in potassium channel inairway smooth muscle in asthmatics, which plays a role in BHR in some extent; (2) p0tassium channel ac-tivators, such as Lemakalim, might be useful in prophylaxis and treatment of asthma.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1997年第1期44-46,共3页
Academic Journal of Second Military Medical University
基金
国家自然科学基金!39370327
关键词
哮喘
药物疗法
钾通道激活剂
Lemakalim
BHR
potassium channel
potassium channel activator
Lemakalim
bronchial hyperresponsiveness
asthma
