摘要
目的探讨巨细胞病毒(CMV)感染与急性心肌梗死的关系。方法分别采用酶联免疫吸附试验(ELISA)和聚合酶链反应(PCR)技术测定51例急性心肌梗死、42例陈旧性心肌梗死患者及冠脉造影正常的31例正常对照者、33例非冠心病患者血CMV抗体水平及DNA,同时检测各组的超敏C反应蛋白(hsCRP)、可溶性细胞间黏附分子1(sICAM-1)、白细胞介素6(IL-6)变化。结果急性心肌梗死组(治疗前)CMV IgG,CMV IgM阳性率及水平显著高于正常对照组、非冠心病组(均P<0.01),CMV DNA检测结果与之吻合。校正冠心病危险因素前后,CMV IgG阳性均与急性心肌梗死有相关性(分别:OR=3.262,P=0.021;OR=3.047,P=0.030)。急性心肌梗死组治疗前hsCRP,sICAM-1,IL-6均显著高于其他各组(均P<0.01);急性心肌梗死组中CMV IgG(+)组与同组CMV IgG(-)组比较,hsCRP,sICAM-1,IL-6均显著升高(P<0.01);IgG水平与hsCRP,sICAM-1,IL-6呈正相关。结论急性或激活性CMV感染与急性心肌梗死的发生有关,CMV感染可能通过激发和加重冠状动脉内炎症反应,参与动脉粥样硬化、急性心肌梗死的病理过程。
Objective To investigate the correlation between cytomegalovirus infection and acute myocardial infarction （AMI）. Methods CMA antibody level and DNA of 51 patients with AMI, 42 patients with old myocardial infarction, 31 normal controls and 33 patients without coronary artery disease were measured by ELISA and PCR methods. The levels of hypersensitive C-reactive protein （hsCRP）, soluble intercellular adhesion molecule-1 （slCAM-1） and interleukin- 6 （IL-6） were also determined. Results The positive rates and levels of CMV IgO, CMV IgM in AMI group before treatment were significantly higher than that in control and non-coronary artery disease group （both P 〈 0.01 ）, CMV DNA results were identical with the above results. Before and after the adjustment of cardiovascular risk factors, CMV IgG were both correlated with AMI （ OR = 3. 262, P = 0. 021 ; OR = 3. 047, P = 0. 030 ; respectively）. The levels of hsCRP, sICAM-1 and IL-6 in the AMI group before treatment were all higher than that in the other groups （all P 〈7 0.01）. In AMI group, those who were CMV IgG positive had significant higher levels of hsCRP, sICAM-1 and IL-6 than those who were CMV IgG negative （ P 〈0.01）. The level of IgG antibody was positively associated with the level of hsCRP, sICAM-1 and IL-6. Conclusion There is significant correlation between acute or active CMV infection and AMI. CMV infection may be involves in the pathogenesis of atherosclerosis and myocardial infarction by inducing and accelerating coronary artery inflammation.
出处
《中国感染控制杂志》
CAS
2006年第2期108-112,共5页
Chinese Journal of Infection Control
基金
贵州省科学基金资助项目(黔科合字19991177号)
关键词
心肌梗死
巨细胞病毒
C反应蛋白
细胞间黏附分子1
白细胞介素6
myocardial infarction
cytomegalovirus virus
C-reactive protein
intercellular adhesion molecule-1
inter- leukin-6
