摘要
目的研究幽门螺杆菌(Hp)感染与脑梗死(CI)的相关性。方法选择102例无明显消化道症状的脑梗死患者,72例年龄性别匹配的健康对照者,采用单克隆抗体蛋白芯片方法检测血清中的细胞毒素相关蛋白(CagA)、尿素酶(Ure)和空泡细胞毒素(VacA)3种Hp抗体,比较两组抗体的阳性率及菌株分型的差异,分析脑梗死发生的危险因子。结果CI组血清中的CagA、Ure、VacA抗体的阳性率和Hp的感染率分别为:46.1%、88.2%、48.0%、88.2%,对照组相应的阳性率为:18.1%、43.1%、19.4%和43.1%,两组之间差异有非常显著意义(P<0.01);其中CI组90例Hp感染者菌株分型比例为:Ⅰ型33.3%、Ⅱ型26.7%、中间型40.0%,2对照组32例Hp感染者菌株分型比例为:Ⅰ型15.6%、Ⅱ型53.1%、中间型31.3%,两组的菌株型差异有显著意义(P<0.05)。结论Hp感染是脑梗死发生的危险因子之一,Ⅰ型Hp感染者比Ⅱ型Hp感染者患CI的危险性更大。
Objective To study the relationship between Helicobacter pylori（Hp） infection and cerebral ischemia （CA）. Methods We detennined the antibodies against CagA, Ure and VacA of Hp（monocolon protein chip technique） in 102 patients with CA without digestive system symptom and in 72 age- and sexmatched control subject from the general population. At the same time analyze risk factors of CI. Results The seropositivity of the antibody against CagA, Ure , VacA and Hp infection in patients is 46.1%, 88.2 % ,48.0%, 8,8.2 %, and the sempositivity of control subject is 18.1% ,43.1%, 19.4 % ,43.1%. There is signitlcantly different betwee CA and control subject （ P 〈 0.01 ） .The rate of Type Ⅰ , type Ⅱ and type middle in 90 CA group who infected Hp is 33.3 %, 26.7 % ,40.0%, The rate of that in 32 control group is 15.6 % ,53.1% ,31.3 %. The difference of the types of Hp were significant between CA and control（ P 〈0.05）. Conclusion Helicobacter pylori infection is one of the risk factor of cerebral ischemia.Tbe danger in those patient who infect type Ⅰ of Hp is more than that of type Ⅱ.
出处
《中国实验诊断学》
2006年第8期826-828,共3页
Chinese Journal of Laboratory Diagnosis
关键词
蛋白芯片
幽门螺杆菌
脑梗死
抗体
protein chip
Helicobacer pylori
cerebral ischemia
antibody
