摘要
采用香兰素和乙酰丙酮为原料,在碱作用下通过Claisen缩合反应直接合成姜黄素.结果表明,有机碱、反应时间、温度以及静置陈化时间的不同,姜黄素的收率不同;采用三乙胺作碱,经预处理4 h,维持温度50℃下反应4 h,静置陈化48 h的条件下产率最高,可达到69%.
Application of acethylacetone and vanillin in alkali to the directly synthesis of curcumin（ 1,7-bis（4-hydroxy-3- methoxyphenyl）-1,6-heptadiene-3,5-dione） by Claisen condensation reaction is reported. The result indicate that different organic alkali, reaction temperature , reaction time as well as deposited time have different attainability of curcumin. Adopting triethylamine as an alkali, keeping four hours fore-disposal time, four hours reaction time at 50 ℃ and 48 hours deposited time, the yield rate of curcumin is more higher than others conditions and reach to 69%.
出处
《江西师范大学学报（自然科学版）》
CAS
北大核心
2007年第3期282-284,共3页
Journal of Jiangxi Normal University(Natural Science Edition)
基金
广西中医学院高学历科研启动基金资助项目(2004G023)
关键词
香兰素
乙酰丙酮
姜黄素
克莱森缩合反应
vanillin
acethylacetone
curcumin
Claisen condensation reaction
