摘要
绝大多数感音神经聋是由毛细胞和与之相联系的螺旋神经的损伤或退化造成。哺乳动物内耳缺乏再生能力。近年研究发现,哺乳动物内耳存在干细胞,但处于静止状态。从各种干细胞培育耳蜗祖细胞来补充损失的毛细胞和螺旋神经元为感音神经聋的治疗带来新的希望。胚胎干细胞、神经干细胞、内耳干细胞、骨髓间充质干细胞都可向耳蜗祖细胞分化,在内耳存活并进一步分化成毛细胞和螺旋神经元。关于如何诱导干细胞向内耳环细胞分化的研究也取得了一定进展。
Most case of sensorineural deafness can be attribute to the impairment and degeneration of hair cell and associated spiral ganglion neurons. The mammalian inner ear has limited regenerative ability. It has been demonstrated recently that there are stem ceils exited in the mammahan inner ear although they are in quiescent state. Replacement of lost cochlear hair cells and spiral ganglion neurons with appropriate cochlear progenitor cells derived from various stem cells offers a viable option for the therapy of this diseases.. Embryonic stem cells, neural stem cells, stem cells in the inner ear and bone-marrow stem cell neural stem cells are all have the potential ability to differentiate into cochlear progenitor cells and then the survival can further to hair cell and spiral ganglion neurons. Some progresses have achieved on how to induce stem ceils to diferentiate into cochlear progenitor cells.
出处
《医学综述》
2007年第11期819-821,共3页
Medical Recapitulate
关键词
聋
干细胞
毛细胞
再生
Deafness
Stem Cells
Hair Cells
Regeneration
