摘要
目的探讨慢性心力衰竭(CHF)患者血清血管紧张素Ⅰ(AⅠ)、血管紧张素Ⅱ(AⅡ)、心钠素(ANF)和醛固酮(ALD)水平,及经螺内酯(安体舒通)干预治疗后的变化及其临床意义。方法放射免疫法测定CHF组120例和40例对照组血清AⅠ、AⅡ、ANF和ALD水平,对其中66例原发性高血压(DH)患者给予螺内酯干预治疗,测定其治疗前后上述血管活性肽变化。结果CHF患者血清AⅠ、AⅡ和ALD显著高于对照组(t=5.487,t=4.179,t=13.89;P均<0.01),ANF显著低于对照组(t=3.128,P>0.01)。Ⅱ、Ⅲ、Ⅳ级心功能组间AⅡ和ALD水平依次显著升高(FAⅡ=7.850,P<0.01;FALD=3.558,P<0.05)。CHF组中,66例经平均88.7(89±24)d的螺内酯干预治疗后平均AⅡ显著升高(t=2.107,P<0.05),AⅠ、ANF和ALD均无显著变化(P均>0.05)。结论CHF患者血清AⅠ、AⅡ和ALD显著升高,ANF显著下降。经螺内酯治疗后,AⅡ显著升高,但AⅠ、ANF和ALD无明显改变。
Objective To study the effects of spironolactone on the serum angiotensin Ⅰ （A Ⅰ ）, angiotensin Ⅱ （A Ⅱ ） ,atrial natriuretic factor （ANF） and aldosterone （ALD） levels for chronic heart failure （CHF） patients,and its clinical significance. Methods A Ⅰ ,A Ⅱ ,ANF and ALD levels were determined by radioimmunoassay in 120 patients with CHF,and 40 patients without EH save as control group. Among the 120 patient,66 cases were determined repeatly after treatment by spironolactone. Resuit It showed that mean serum A Ⅰ ,A Ⅱ and ALD levels in CHF patients were significantly higher than in control proup cases （ t =5.487, t =4. 179, t = 13.89; P 〈0. 01 ） ,but the mean serum ANF level was significantly lower （ t =3. 128, P 〈0. 05）. The A Ⅱ and ALD levels increased by degrees in different step patients （NYHA Ⅱ ,Ⅲ ,Ⅳ） （ FAⅡ =7. 850, P 〈0. 01 ; FALD = 3. 558, P 〈0. 05）. In 66 cases after treatment of spironolaetonel,the A Ⅰ ,ANF and ALD levels had no significant changes,but the A Ⅱ levels was significantly decreased（ t = 2. 107, P 〈 0.05）. Conclusion In CHF patients,A I ,A Ⅱ and ALD levels, were significantly higher,and ANF was significantly lower than in control proup cases. After treatment by spironolactonel, A I , AFN and ALD levels were no difference,but A Ⅱ levels was significantly decreased.
出处
《临床医学》
CAS
2007年第6期22-23,共2页
Clinical Medicine
关键词
心力衰竭
血管紧张素Ⅰ
血管紧张素Ⅱ
心钠素
醛固酮
螺内酯
Chronic heart failure
Angiotensin Ⅰ
Angiotensin Ⅱ
Atrial natriuretic factor
Aldosterone
Spironolactone
