摘要
目的探讨晚期日本血吸虫病患者肝组织CD34表达和微血管密度变化与肝纤维化程度的关系。方法应用免疫组化方法检测35例晚期血吸虫病患者及5例对照组患者肝组织标本的CD34表达,同时光镜下测定肝脏微血管密度。结果晚期血吸虫病患者肝组织CD34表达及肝脏微血管密度随肝纤维化程度的进展而增加,CD34表达和肝脏微血管密度均与肝纤维化分期呈正相关。结论CD34表达和肝脏微血管密度可以作为临床观察晚期血吸虫病肝纤维化患者肝窦病变的重要组织学指标。
Objective To explore the relationship between CD34 expression or microvessel density and hepatic fibrosis degree in advanced schistosomiasis patients. Methods Thirty-five advanced schistosomiasis patients and 5 control patients were included in this study. CD34 expression in liver tissue was measured with immunohistochemistry while microvessel density （MVD） of liver tissue was evaluated under a light microscope. Results CD34 expression and MVD value were significantly correlated with hepatic fibrosis degree in liver tissue from the advanced schistosomiasis patients. Conclusions CD34 expression and MVD value are two histological parameters representing the liver sinusoid changes during fibrogenesis in advanced schistosomiasis patients.
出处
《中国血吸虫病防治杂志》
CAS
CSCD
2007年第3期200-202,共3页
Chinese Journal of Schistosomiasis Control
关键词
日本血吸虫病
肝纤维化
肝窦
CD34
微血管密度
Schistosomiasis japonica
Hepatic fibrosis
Liver sinusoid
CD34 Microvessel density
