摘要
目的探讨腹部创伤早期腹腔内注射利多卡因止痛对腹部创伤急性腹膜炎炎症反应的作用及其机制。方法将16只家兔随机分为2组,即单纯创伤组和盐酸利多卡因处理组。手术制作由锐器伤引起的胆囊破裂和肠内容物流入腹腔而形成的较为严重的胆汁性腹膜炎和早期开放性腹部损伤模型。单纯创伤组腹腔内注射无菌生理盐水,利多卡因处理组腹腔内注射盐酸利多卡因。测定2组的白细胞总数、中性粒细胞百分比及TNF-α等炎性介质的浓度。结果两组实验兔血液中白细胞总数、中性粒细胞百分比、TNF-α均有升高,与各自组创伤前比较,均有显著性差异(P<0.05)。创伤后同一时间点单纯创伤组各观察指标平均值均大于盐酸利多卡因处理组。结论早期腹腔内注射盐酸利多卡因止痛可通过交感-肾上腺髓质系统外周反应系统改变机体血管状态,改善创伤部位的血流状态及炎症反应水平,有利于促进炎症的好转。
Objective To investigate the effects of analgesia injection of lidocaine into abdomen on early inflammatory response after abdominal trauma and the mechanism. Methods Sixteen rabbits were randomly divided into two groups, including control group（abdominal injection of saline alone, n = 8）and treatment group（abdominal injection of lidocaine,n = 8）. The abdominal trauma models in rabbits were established by surgical operation. The number of white blood ceils, the percent of neutrophile granulocytes and levels of TNF-α were determined. Results The number of white blood cells, the percent of neutrophile granulocytes and levels of TNF-α in control and treatment groups were elevated as compared with those before abdominal trauma（P〈0. 05）, and those in treatment group were significantly lower than those in control group. Conclusion Analgesia injection of lidocaine into abdomen in the early stage of abdominal trauma may change vasopermeability and improve blood flow by sympa- thetic-adrenal medullary system and peripheral improve the general status of patients. response system, which can reduce inflammation and
出处
《腹部外科》
2007年第3期184-185,共2页
Journal of Abdominal Surgery
关键词
腹部损伤
止痛
炎症
利多卡因
Abdominal injuries
Analgesia
Inflammation
Lidocaine
