摘要
目的研究急性胰腺炎患者发病及治愈后T细胞亚群及补体的变化。方法检测29例急性胰腺炎患者发病后和治愈后T淋巴细胞亚群及补体C3、C4,进行治疗前后比较并与对照组比较。结果急性胰腺炎发病后其T淋巴细胞亚群中CD3+、CD4+细胞和CD4+/CD8+比值均下降;血清补体C3、C4水平有不同程度的下降,以重症急性胰腺炎最明显;随着疾病的治愈,机体免疫功能逐步恢复,上述免疫学指标也大都能恢复到正常水平,但重症急性胰腺炎组C3、C4仍较正常低。结论急性胰腺炎患者存在不同程度的免疫功能损害,以重症急性胰腺炎明显。
Objective To examine the changes of T cell subpopulation and complement before and after the treatment of acute pancreatitis. Metheod T cell subpopulation and complement C3, C4 were measured in 29 patients with acute pancreatitis at the onset and after the treatment, and they were com-pared with healthy controls. Result The ratio of CD^＋3, CD^＋4 and CD^＋4/CD^＋8 T cell was reduced in all pa-tients with acute pancreatitis and also in complement CD^＋3, CD^＋4 but it was specially obvious in patients with severe acute pancreatitls. Body immunofunction was recovered after the treatment of the desease and the immunity index also reached towards normal, but complements C3, C4 in patients with severe acute pancre-atitis were still lower than normal. Conclusion Immunofunctional impairment occurs in patients with a-cute pancreatitis.especially in those with severe acute pancreatitis.
出处
《临床内科杂志》
CAS
2007年第6期403-404,共2页
Journal of Clinical Internal Medicine
关键词
急性胰腺炎
T淋巴细胞亚群
补体
Acute pancreatitls
T-lymphocyte subsets
Complement
