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小剂量沙利度胺联合化疗治疗多发性骨髓瘤的临床观察 被引量:4

Clinic observation on combining low-dose thalidomide with chemotherapy together to cure mutiple myeloma
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摘要 目的 观察小剂量沙利度胺联合化疗治疗多发性骨髓瘤的疗效。方法 14例患者均给予小剂量沙利度胺联合化疗,沙利度胺的剂量为150~200mg/d.根据血清M蛋白和骨髓瘤细胞的减少及血红蛋白的升高判断疗效。结果 有效率为80%,不良反应小。结论 小剂量沙利度胺联合化疗治疗可作为治疗多发性骨髓瘤的有效治疗方法。 Objective To observe the curative effect of low-dose thalidomide combined with chemotherapy together in curing mutiple myeloma(MM). Methods 14 MM sufferers were selected to receive the above curative therapy. The dose of thalidomide was 150 - 200mg/day. The curative effect could be estimated through observing the decrease of serum myeloma protein and myeloma cells and the increase of hemoglobin. Results The observation result showed thai our curative scheme was rather good for MM in 80% and that no poison or side effects were found. Conclusion It proves that low-dose thalidomide with chemotherapy together can be taken as an effective curative therapy on MM.
出处 《中国基层医药》 CAS 2007年第5期756-757,共2页 Chinese Journal of Primary Medicine and Pharmacy
关键词 多发性骨髓瘤 沙利度胺 剂量 化疗 Mutiple myeloma Thalidomide
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参考文献5

  • 1张之南主编..血液病诊断及疗效标准 第2版[M].北京:科学出版社,1998:434.
  • 2Hales B. Thalidomide sabourin on the comebacktrail. Nat Med, 1999,5:489. 被引量:1
  • 3Singhal S, Mehtu J, Desikan R, et al. Antitumor activity of thalidomide in refractory multiple myeloma. N Engl J Med, 1999,341 (21) : 1565. 被引量:1
  • 4Raje NR, Anderson K. Thalidomide a revival story. N Engl J Med. 1999,341 : 1606. 被引量:1
  • 5Teosk, Sabourin PJ, O'Brien K, et al. Metabolism of thalidomide in human microsomes, cloned human cytoehrome p450 isozymes, and Hansen' disease patients. J Biochem Mol Toxicol,2000,14(3) : 140- 147. 被引量:1

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