摘要
目的评估序贯结肠透析、血液透析及腹膜透析3种透析方式对高尿酸血症患者尿酸水平的影响。方法对293例高尿酸血症患者应用数字随机法分组,采用序贯结肠透析、血液透析及腹膜透析3种不同治疗方式,根据血尿酸水平分轻、中、重度组,应用尿酸酶—过氧化酶法,测定透析前后血尿酸水平,同时自动生化分析仪检测K+、Na+、Cl-、Ca2+水平及体重等指标的变化。结果293例患者中,血尿酸水平轻度组3种治疗方式差异无显著性(P>0.05),中度组血液透析及腹膜透析与序贯结肠透析比较,差异有显著性(P<0.01),血液透析与腹膜透析之间比较差异无显著性(P>0.05),重度组血液透析、腹膜透析与序贯结肠透析比较,差异均有显著性(P<0.01);治疗前后K+、Na+、Cl-、Ca2+水平及体重等指标无明显变化(P>0.05)。结论序贯结肠透析同血液透析、腹膜透析一样均可有效降低高尿酸血症患者血尿酸水平,减少高尿酸血症并发症的发生。
Objective To evaluate the effects of sequential colon dialysis （SCD）, hemodialysis （HD） and peritoneal dialysis （PD） on the serum level of uric acid （UA） in patients with hyperuricemia. Methods A total of 293 patients with mild, moderate and severe degree of hyperuricemia were randomly assigned to three groups according to digital randomized method, and treated with SCD, HD and PD respectively. The serum level of UA was determined with unicase-peroxidase conjugate method, the blood levels of K^＋ , Na^＋ , Cl^-, Ca^2＋ were determined by automatic biochemical analysor, and changes of body weight were measured before and after dialysis. Results In the 293 cases, the three modes of dialysis showed no difference in lowering uric acid in patients of mild degree （P〉0.05）. But the HD did show a better efficacy than that of the other two in severe degree patients （ P 〈0.01）, while in patients of moderate degree, significant difference （ P 〈 0.01） showed between HD and SCD, PD and SCD, but not between HD and PD （P 〉0.05）. No obvious effect of the various modes of dialysis on the level of K^＋ , Na^＋ , Cl^- , Ca^2＋ , body weight. Conclusion SCD can decrease the serum level of UA effectively and reduce the incidence of complication of hyperuricemia to some extent, as hemodialysis and peritoneal dialysis can.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2007年第6期492-494,共3页
Chinese Journal of Integrated Traditional and Western Medicine
基金
广东省中医药局基金资助项目(No.1040138)
关键词
序贯结肠透析
血液透析
腹膜透析
高尿酸血症
sequential colon dialysis
hemodialysis
peritoneal dialysis
hyperuricemia
