摘要
目的:研究生脉散对应激小鼠组织氧化损伤的预防作用。方法:通过剪除小鼠胡须的方式造成氧化应激模型,以羰基蛋白(carbonyl protein)、硫代巴比妥酸反应物(thiobarbituric acid reactive substance,TBARS)作为衡量氧化损伤的指标对生脉散的抗氧化能力进行评价。结果:应激小鼠自主活动次数显著增高,预先灌服生脉散可抑制这种增高。应激小鼠脑、心、肝、肾组织中的羰基蛋白量的升高和心、肝组织中的TBARS增高,可以被生脉散抑制。结论:生脉散对应激小鼠组织氧化损伤有防治作用。
AIM： To investigate the preventive effects of Shengmai San （SMS） on oxidative damage in mentally stressed mice. METHODS： An oxidative stress mouse model was established by moustache - removed. Protein carbonyl and thiobarbituric acid reactive substance （TBARS） formation were determined as the oxidative stress markers. RESULTS ： （ 1 ） Moustache - cut was founded to significantly enhance the behavioral movements of mice, especially large movements （movement 2 and rearing）. SMS pre- administration inhibited the accelerated movements. （2） Protein carbonyl was increased in brain, heart, liver and kidney. TBARS in liver and heart increased in the moustache - cut mice, but SMS pretreatment inhibited the increased protein carbonyl and TBARS. CONCLUSION： SMS has the preventive effects on oxidative damage induced by emotional stress.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2007年第6期1216-1218,共3页
Chinese Journal of Pathophysiology
基金
2005年中医药留学回国人员科技活动择优资助项目(No.国中医药研2005LHR17号)
关键词
生脉散
氧化损伤
羰基蛋白质
硫巴比妥酸反应物
Shengmai San
Oxidative injury
Protein carbonyl
Thiobarbituric acid reactive substances
