摘要
随着生存的改善,乳腺癌中枢神经系统转移发生几率有所增加。综合多项研究,年轻、雌激素受体阴性、HER-2过表达、已存在肺转移是可能的预测因素。新的化疗和靶向治疗药物,尤其是lapatinib,一个口服的双靶点小分子酪氨酸激酶抑制剂,为乳腺癌中枢神经系统转移患者的治疗提供了新的选择。
With the improvement in survival of patients of breast cancer, central nervous system (CNS) metastases is increasing. Younger age, estrogen receptor (ER) negativity, HER - 2 overexpression and lung metastases are predictive factors. New chemotherapy and targeted therapy agents, especially lapatinib, a oral dual HER- 1/2 tyrosine kinase inhibitor, provide new options for these patients.
出处
《癌症进展》
2007年第3期233-237,259,共6页
Oncology Progress