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乳腺癌中枢神经系统转移的预测因素和内科治疗 被引量:1

Predictive factors and systemic therapy for breast cancer metastatic to the central nervous system
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摘要 随着生存的改善,乳腺癌中枢神经系统转移发生几率有所增加。综合多项研究,年轻、雌激素受体阴性、HER-2过表达、已存在肺转移是可能的预测因素。新的化疗和靶向治疗药物,尤其是lapatinib,一个口服的双靶点小分子酪氨酸激酶抑制剂,为乳腺癌中枢神经系统转移患者的治疗提供了新的选择。 With the improvement in survival of patients of breast cancer, central nervous system (CNS) metastases is increasing. Younger age, estrogen receptor (ER) negativity, HER - 2 overexpression and lung metastases are predictive factors. New chemotherapy and targeted therapy agents, especially lapatinib, a oral dual HER- 1/2 tyrosine kinase inhibitor, provide new options for these patients.
作者 吴卫华 李青
出处 《癌症进展》 2007年第3期233-237,259,共6页 Oncology Progress
关键词 乳腺癌 中枢神经系统转移 预测因素 内科治疗 breast cancer CNS metastases predictive factor systemic therapy
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