摘要
γ-谷氨酰半胱氨酸合成酶（γ-GCS）是谷胱甘肽（GSH）合成的限速酶，其表达水平与活性对支气管哮喘（哮喘）有重要意义，核因子相关因子2（NF-E2 related factor2，Nrf2）能调控γ-GCS的表达。细胞外信号通过细胞内Keapl、Bachl、PERK等多种因素调节Nrf2的活性，而导致γ-GCS的活性改变，最终使得GSH含量改变，而参与哮喘发病过程。
The expression level and activity of gamma-glutamyl-cysteine synthetase（γ-GCS） ,which is the rate-limiting enzyme catalyzing GSH biosynthesis,plays a critical role in the bronchial asthma（asthma）, NF-E2 nelated factor2（Nrf2） can regulate the expression of γ-GCS. Extracellular signals can modulate the activity of Nrf2 via many intracellular factors such as Keapl,Bachl, PERK, resulting in alteration of γ-GCS activity and finally changing the level of GSH,thereby they take part in the asthma development.
出处
《国际呼吸杂志》
2007年第11期819-822,共4页
International Journal of Respiration
