摘要
[目的]前瞻性观察贲门脊根部黏膜形态异常病例的癌变情况,为提高对贲门高发部位的认识提供依据。[方法]851例内镜检查中发现的贲门脊根部黏膜充血、粗糙和糜烂等形态异常,但活检病理报告阴性的32例患者作为研究组,选择同时、同村、相同年龄和性别的79例黏膜正常,活检报告也为阴性者作为对照组。两组全部对象进行前瞻性随访15年。[结果]研究组32例中18例演变为贲门癌,癌变率为56.25%。对照组79例中4例发生贲门癌,癌变率为5.06%(P<0.01)。[结论]贲门脊根部黏膜异常改变应视为癌前状态,宜定期随诊。
[Purpose] To investigate the canceration rate of mucosal abnormality at the root of cardiac mucosal ridge. [Methods ] Of 851 cases undergoing endoscope examination, 32 cases with mucosal abnormality including congestion, roughness or erosion on the cardiac mucosal ridge root and biopsy proved no cancer were selected as the study group. Seventy-nine normal mucosal cases matching with sex, age and area were selected as control group. All cases in the 2 groups were prospective followed-up for 15 years after the initial endoscope examination.[Results ] After 15 years follow-up, 18 cases were diagnosed as gastric cardiac cancer in study group, the canceration rate was 56.25% （18/32）. Only 4 cases were diagnosed as gastric cardiac cancer in the control group, the canceration rate was 5.06% （4/79）（P〈0.05）. [Conclusion] The mucosal abnormality at root of cardiac mucosal ridge should be considered as precancerous status and followed -up periodically.
出处
《中国肿瘤》
CAS
2007年第6期453-454,共2页
China Cancer
