摘要
目的探讨水杨酸钠导致耳鸣动物模型的下丘和听皮层内5-羟色胺神经递质的变化。方法利用微透析技术,在水杨酸钠导致的耳鸣动物模型上,监测水杨酸钠对下丘和听皮层内5-羟色胺系统的影响。结果腹腔注射水杨酸钠(350mg/kg)引起下丘和听皮层葡萄糖和乳酸水平显著增高,反映局部神经元活动增加。下丘和听皮层部位5-羟色胺的释放分别在给药后2小时和3小时最高,达到基础值的(268±27)%和(277±24)%。结论本研究表明下丘和听皮层内5-羟色胺水平的升高可能和耳鸣的产生有关。
OBJECTIVE The characterization of neurotransmitters＇ changes induced by salicylate in the inferior colliculus （IC） and the auditory cortex （AC） may provide insight into the action of salicylate on the auditory system and, through this, provide a better understanding of neurological mechanism of salicylateinduced tinnitus. METHODS In the present study, the effect of salicylate on 5-HT system in IC and AC has been monitored by microdialysis in salicylate-induced tinnitus animal models. RESULTS Glucose and lactate levels in IC and AC were significantly increased after application of salicylate （350 mg/kg, i.p.）, indicating a salicylate related increase in regional neuronal activity. The 5-HT level increased to a maximum of （268±27） % basal level in IC 2 h after application and of （277±24） % basal level in AC around 3 h after application. CONCLUSION These data suggest that the increases of 5-HT levels in IC and AC may be involved in the tinnitus generation.
出处
《中国耳鼻咽喉头颈外科》
北大核心
2007年第4期203-206,共4页
Chinese Archives of Otolaryngology-Head and Neck Surgery
关键词
水杨酸钠
大鼠
耳鸣
血清素
Sodium Salicylate
Rats
Tinnitus
Serotonin
