摘要
目的观察不稳定型心绞痛(UAP)患者接受冠状动脉介入术(PCI)治疗前后C-反应蛋白(CRP)及肌钙蛋白I(cTnI)的变化及其对预后的预测价值。方法选择2002年3月至2004年12月在广东省江门市人民医院住院并接收PCI治疗的87例UAP患者,术前及术后1,12,24,48h分别测定血浆CRP及cTnI水平,并分析术前术后的变化,将PCI术后12hCRP>3.0mg/L、cTnI>2.0μg/L的65例患者作为A组;其他22例为B组作对照,分析CRP、cTnI与冠脉病变程度,球囊扩张次数、压力、时间、支架置入数及合并症的关系,观察CPR、cTnI的水平与住院期间及随防1年患者恶性心脏事件发生率的关系。结果87例UAP患者PCI治疗后,CPR、cTnI均明显升高(P均<0.05)。CPR、cTnI与冠脉病变的程度,球囊扩张的次数、压力、时间、支架置入数及合并症呈正相关。(A组与B组比较,P<0.05),A组住院期间及随防期间恶性心脏事件的发生率显著高于B组(P<0.05)。结论PCI治疗会引起UAP患者炎症激活及心肌损伤,且对术后的临床预后有一定的预测价值。
Objective To study variation of plasma C-reative protein （CRP） levels and serum cardiac troponin I （cTnI） before and after percutaneous coronary intervention（PCI） in unstable angina pectoris （UAP）patients, and explore its prognostic predictive value. Methods The plasma CRP levels and cTnI levels of 87 patients were measured before PCI, immediately after as well as 1 h,12 h ,24 h and 48 h later. The patients were separated into 2 groups according to CRP and cTnI levels,Group A（high level） ：CRP 〉3 mg/L,and CTnI 〉2.0 μg/L,n =65 cases;Group B（low level） ：CRP 〈3 mg/ L or CTnI 〈 2.0 μg/L, n = 22 cases. Then we analysed the plasma CRP and （cTnI） levels with the severity extent of coro- nary, the number, pressure and time of balloon angioplasty, the number of stents and complications. We followed up for 12 months and accounted the rate of acute cardiac events. Results The levels of CRP,cTnI were significantly higher in all patients after PCI（P 〈 0.05） ;the CRP and cTnI levels had positive correlation with the severity extent of coronary, the number, pressure, and time of balloon angioplasty, the number of stents and complications. The rate of acute cardiac events of Group A was obviously higher than that of Group B （P 〈 0. 05 ）. Conclusion Lesions in inflammatory response with PCI might affect the prognosis of unstable angina pectoris （UAP） patients, and the levels of CRP and cTnI might have clinical predictive value.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2007年第12期962-964,共3页
Chinese Journal of Practical Internal Medicine
