摘要
系统性红斑狼疮、特别是狼疮性肾炎患者经常合并各种动、静脉血栓,其发生机制主要与免疫炎症激活内、外源性凝血途径和损伤内皮细胞有关;抗凝治疗可以阻断炎症与凝血间的正性循环,从而不仅可以防治血栓栓塞性疾病,而且可以减轻狼疮性肾炎的肾脏组织炎症反应,减轻肾脏损害。
Patients with systemic lupus erythematosus, especially lupus nephritis, are often accompanied by arterial and venous thrombus at various sites. Thrombosis is associated with the extrinsic and intrinsic coagulation pathway activated by inflammation and endothelium injury. Anticoagulant therapy can interrupt the cycle between inflammation and thrombus, which not only prevents and treats the thrombotic disease but also lessens the inflammatory reaction in kidney and attenuates the renal injury.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2009年第6期507-509,共3页
Chinese Journal of Practical Internal Medicine
关键词
狼疮性肾炎
血栓栓塞
抗凝治疗
lupus nephritis
thromboembolism
anticoagulant therapy