期刊文献+

狼疮性肾炎合并血栓栓塞与抗凝治疗 被引量:2

Thromboembolism and anticoagulant therapy in patients with lupus nephritis
原文传递
导出
摘要 系统性红斑狼疮、特别是狼疮性肾炎患者经常合并各种动、静脉血栓,其发生机制主要与免疫炎症激活内、外源性凝血途径和损伤内皮细胞有关;抗凝治疗可以阻断炎症与凝血间的正性循环,从而不仅可以防治血栓栓塞性疾病,而且可以减轻狼疮性肾炎的肾脏组织炎症反应,减轻肾脏损害。 Patients with systemic lupus erythematosus, especially lupus nephritis, are often accompanied by arterial and venous thrombus at various sites. Thrombosis is associated with the extrinsic and intrinsic coagulation pathway activated by inflammation and endothelium injury. Anticoagulant therapy can interrupt the cycle between inflammation and thrombus, which not only prevents and treats the thrombotic disease but also lessens the inflammatory reaction in kidney and attenuates the renal injury.
出处 《中国实用内科杂志》 CAS CSCD 北大核心 2009年第6期507-509,共3页 Chinese Journal of Practical Internal Medicine
关键词 狼疮性肾炎 血栓栓塞 抗凝治疗 lupus nephritis thromboembolism anticoagulant therapy
  • 相关文献

参考文献12

  • 1Kaiser R,Cleveland CM,Criswell LA.Risk and protective factors for thrombosis in systemic lupus erythematosus:results from a large,multi-ethnic cohort[J].Ann Rheum Dis,2009,68 (2):238-241. 被引量:1
  • 2Romero-Diaz J,Garcia-Sosa I,Sanchez-Guerrero J.Thrombosis in systemic lupus erythematesus and other autoimmune diseases of recent ouset[J].J Rheumatol,2009,36(1):68 -75. 被引量:1
  • 3Tektonidou MG,Laskari K,Panagiotakos DB,et al.Risk factors for thrombosis and primary thrombosis prevention in patients with systemic lupus erythematosus with or without antiphospholipid antibodies[J].Arthritis Rheum,2009,61 (1):29 -36. 被引量:1
  • 4Choojitarom K,Verasertniyom O,Tctemehokchyakorn K,et al.Lupus nephritis and Raynaud's phenomenon are significant risk factors for vascular thrombosis in SLE patients with positive antiphospholipid antibodies[J].Clin Rheumatol,2008,27 (3):345-351. 被引量:1
  • 5Shaft ST,Gupta M.Risk of vascular access thrombosis in patients with systemic lupus erythematosus on hemodialysis[J].J Vasc Access,2007,8(2):103 -108. 被引量:1
  • 6叶任高,孙雪峰.要进一步研究狼疮性肾炎的凝血异常[J].广东医学,2003,24(5):453-454. 被引量:4
  • 7Bizzaro N,Ghirardello A,Zampieri S,et al.Anti-prothrombin antibodies predict thrombosis in patients with systemic lupus erythematosus:a 15-year longitudinal study[J].J Thromb Haemost,2007,5(6):1158 -1164. 被引量:1
  • 8Bertolaccini ML,Mepani K,Sanna G,et al.Factor Ⅻ autoantibodies as a novel marker for thrombosis and adverse obstetric history in patients with systemic lupus erythematosus[J].Ann Rheum Dis,2007,66(4):533 -536. 被引量:1
  • 9Wu H,Birmingham DJ,Rovin B,et al.D-dimer level and the risk for thrombosis in systemic lupus erythematosus[J].Clin J Am Soc Nephrol,2008,3 (6):1628-1636. 被引量:1
  • 10Meesters EW,Hausen H,Spronk HM,et al.The inflammation and coagulation cross-talk in patients with systemic lupus erythematosus[J].Blood Coagul Fihrinolysis,2007,18(1):21 -28. 被引量:1

二级参考文献20

  • 1Funauchi M, Ikoma S, Enomoto H, et al. Decreased Thl-like and increased Th2-1ike cells in systemic lupus erythernatosus. Scand J Rheumatol, 1998,27: 219-224. 被引量:1
  • 2Tokano Y, Morimoto S, Kaneko H, et al. Levels of IL-12 in the sera of patients with systemic lupus erythernatosus (SLE)-relation to Thl and Th2 derived cytokines. Clin Exp Immunol, 1999, 116:169-173. 被引量:1
  • 3Amit M, Mor A, Weissgarten J, et al. Inactive systerdic lupus erythematosus id associated with a normal stimulated Th1/Th2 cytokine secretory pattern. Cytokine,2000,12:1405-1408. 被引量:1
  • 4Kiraz S, Ertenli I, Benekli M, et al. Clinical significance of hemostatic markers and thrombornodulin in systemic lupus erythematosus: evidence for a prothrombotic state. Lupus, 1999,8 : 737-741. 被引量:1
  • 5Esmon CT . Does inflammation contribute to thrombotic events Haemostasis, 2000,30 (Suppl 2) : 34-40. 被引量:1
  • 6Bombardier C, Gladman DD, Urowitz MB, et al. Derivation of the SLEDAI:a disease activity index for lupus patients: the Committee on prognosis studies in SLE. Arthritis Rheum, 1992,35 : 630-640. 被引量:1
  • 7Maggi E, Biswas P, Prete CD, et al. Accunaulation of Th-2-1ike helper T cells in the conjunctiva of patients with vernal conjunctivitis. J Immunol, 1991,146:1169-1174. 被引量:1
  • 8Romagnani S. Human Thl and Th2 subsets: doubt no more. Immunol Today, 1991,12:256-257. 被引量:1
  • 9Lacki JK, Leszczynski P, Kelemen J, et al. Cytokine concentration in serum of lupus erythematosus patients: the effect on acute phase response. J Med, 1997,28: 99-107. 被引量:1
  • 10Viallard JF, PeUegrin JL, Ranchin V, et al. Thl ( IL-2, interferongamma (IFN-garnma) and Th2 ( IL-10, IL-4) cytokine production by peripheral blood mononuclear cells (PBMC) from patients with systemic lupus erythematosus (SLE). Clin Exp Immunol, 1999, 115:189-195. 被引量:1

共引文献4

同被引文献23

引证文献2

二级引证文献4

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部