摘要
目的探讨姜黄控制微炎症反应后对慢性肾衰非透析患者肾功能的影响。方法选择慢性肾衰非透析患者为研究对象,选定慢性肾脏病（CKD）分期3~4期患者共158例,采用免疫速率比浊法测定高敏C-反应蛋白（hs-CRP,以下简称CRP）的浓度并根据其浓度分为微炎症状态组（58例）和非微炎症状态组（100例）,微炎症状态组再分为治疗组29例和非治疗组29例,治疗组给予姜黄9 g,水煎服1次/d,观察3个月后CRP和肾功能的变化。结果经姜黄治疗3个月后,治疗组CRP水平（3.18±1.74）mg/L显著低于非治疗组（6.39±3.17）mg/L,其变化幅度差异有统计学意义（P〈0.01）,治疗组肾功能指标尿素氮（BUN）、肌酐（Cr）及内生肌酐清除率（Ccr）的变化幅度均显著低于非治疗组（P〈0.01）。结论姜黄可通过控制微炎症反应而延缓慢性肾衰非透析患者肾功能的进展。
Objective To evaluate the variation of renal function after control microinflammation with curcumin in non - dialysis CRF patients. Methods Serum CRP was measured with immunoturhidimetry in 158 non -dialysis patients. Patients were divided into microinflammation group（ n =58） and non-microinflammation group（ n = 100）. All the microinflammation patients were randomly divided into treatment group（ n =29） and non-treatment group（ n =29）. The patients in treatment group were treated with curcumin, and in all microinflammation patients, BUN, Cr, Ccr and CRP were measured after 3 months. Results After 3 months, the mean level of CRP of the treatment group（3.18±1.74 mg/L） was lower than that of non-therapyed group（6. 39±3.17 mg/L） （ P 〈 0. 01 ） , and the mean levels of BUN, Cr, Ccr were also lower than those of non-therapyed group （ P 〈 0. 005 ）. Conclusion Curcumin can delay the progress of renal failure through controlling microinflammation.
出处
《中国医师杂志》
CAS
2007年第5期636-637,共2页
Journal of Chinese Physician
