摘要
目的:介绍康复训练对相关生化化学、基因组学及蛋白质组学的影响。资料来源:检索Medline 2000-01/2005-12与脑梗死或脑缺血、康复训练和大鼠相关的文献,检索词为“cerebral ischemia or cerebral infarction,rehabilitation training or physical training,rat”,并限定语言种类为英语,同时检索中文科技期刊数据库2000-01/2005-12与脑梗死或脑缺血、康复训练和大鼠相关的文献,限定文章语言种类为中文,检索词“脑梗死,康复训练,大鼠”。资料选择:对资料进行初审,选择包含研究目的的基础研究文章,筛除综述类及与目的无关的文章。资料提炼:选出以康复训练对脑梗死或脑缺血大鼠为研究对象的文章60篇。通过阅读摘要或全文对文章内容进行分类整理,其中18篇与本文综述内容关系密切。资料综合:内源性脑保护因子fos即刻早期基因、降钙素基因相关肽、热休克蛋白、胶质纤维酸性蛋白、生长相关蛋白43、N-甲基-D-天冬氨酸受体、一氧化氮合酶、增殖细胞核抗原、S-100蛋白、巢蛋白、脑源性神经营养因子、微管蛋白表达与康复训练效果有关。结论:康复训练可促进脑梗死后大鼠肢体运动功能及学习记忆能力恢复,使梗死灶体积缩小,提高脑组织内保护性蛋白因子的基因表达。
OBJECTIVE： To investigate the effects of rehabilitation training on the biochemistry, genomics and proteome in ischemic rats.
DATA SOURCES：A computer-based online search of Medline database was undertaken to identify articles about rehabilitation training and rats of cerebral infarction or ischemia published in English from January 2000 to December 2005 by using the keywords of ＂rehabilitation training or physical training, cerebral ischemia or cerebral infarction, rat＂. At the same time, Chinese relevant articles were searched in Database of Chinese Scientific and Technical Periodicals between January 2000 and December 2005, with the keywords of ＂cerebral infarction, rehabilitation training, rat＂.
STUDY SELECTION： All the articles were selected firstly, and the basic researches containing the study objective were included while those unrelated to the objective or review articles were eliminated.
DATA EXTRACTION： Sixty articles about the effects of rehabilitation training on rats with cerebral ischemia or cerebral infarction were selected. The contents of literatures were classified and arranged by means of reading the abstracts or full texts, and totally 18 articles were closely related to the content of this review.
DATA SYNTHESIS. The effects of rehabilitation training are related with the expressions of endogenous cerebral protective factor fos immediateearly gene, calcitonin gene-related peptide, heat shock protein, glial fibrillary acidic protein, growth associated protein 43, N-methyl-D-aspartate receptor, nitricoxide synthase, proliferating cell nuclear antigen, S-100 albumen, nidogen, brain-derived neurotrophic factor and tubulin.
CONCLUSION：Rehabilitation training can promote the recovery of limb motor function and the ability of learning and memory in rats after cerebral infarction, contract the volume of ischemic brain and elevate the gene expression of protective protein factor in brain.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2007年第8期1515-1518,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
