摘要
抑郁症的防治已引起世界范围内的重视。通过查阅国内外近年来有关文献结合相关的研究成果,对抗抑郁药物,尤其是天然药物的提取物、活性成分及中药复方的研究进展进行了分类综述;并就药物研究所采用的实验方法(动物模型)的进展情况作了总结,将实验研究方法与临床实际相结合,对其一致性、不足之处、临床价值等方面进行了分析讨论。
Depression, a mental illness marked by feeling of extreme sadness, hopeless and inadequately, has been attached much importance. In this review, we summarized the research development of antidepressants, especially the active constituents, the extracts and the compound Chinese medicine of nature medicine, through consulting the relevant papers; and animal models of depres- sion, have been utilized to screen novel drugs with antidepressant, were compared with clinical efficacy to evaluate the concordance, weak links and clinical values. Although animal models of depression fail to be unequivocally valid, also depression models generally lack both clinical and scientific credibility, they represent the tool to define potential antidepressant activity of drugs by far. Animal modeling remains a potentially important approach towards understanding neurobiological mechanisms in depression.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2007年第9期770-774,共5页
China Journal of Chinese Materia Medica
基金
江苏省自然科学基金项目(BK2005149)
江苏省中医药局中医药科研项目(H05074)
江苏省教育厅自然科学基金项目(02KJB360002)
关键词
抑郁症
天然药物
动物模型
临床效应
depression
natural medicines
animal models
clinical effect
