摘要
蛋白酶激活受体-2(protease activated receptor-2,PAR-2)属于G蛋白耦联受体,具有蛋白酶受体家族较特异的分子结构与激活方式,广泛分布于胃肠道,可被多种蛋白酶激活,产生多种生物学效应,包括影响多种消化腺的分泌,具有胃黏膜保护作用,影响胃肠道运动,参与胰腺炎的发生、发展,与消化道恶性肿瘤密切相关.PAR-2与消化系统疾病的关系正成为当前研究的一个热点.
Protease-activated receptor-2 （PAR-2） is a G-protein-coupled receptor, and its special molecule structure and activation way are similar to other protease-activated receptors. PAR-2 is widely distributed in alimentary system and series of effects are produced when it is activated by certain proteases. For example, PAR-2 exerts gastric mucosal cytoprotective effect, influences the secretion of digestive glands and movement of gastrointestinal tract, participates in the development of pancreatitis, and associates closely with malignant tumors in alimentary system. More and more researches are now focusing on the relationship between PAR-2 and alimentary system diseases.
出处
《世界华人消化杂志》
CAS
北大核心
2007年第9期986-990,共5页
World Chinese Journal of Digestology
关键词
蛋白酶激活受体-2
胃黏膜保护
胰腺炎
癌
Protease activated recerptor-2
Gastric mucosal cytoprotective effect
Pancreatitis
Cancer
