摘要
目的探讨人类免疫缺陷病毒/丙型肝炎病毒(HIV/HCV)混合感染者的免疫淋巴细胞亚群和肝脏生化指标的特征。方法检测并分析研究组(40例混合感染HIV/HCV的血友病患者)和对照组(12例单独感染HIV的血友病患者)若干相关实验室指标。结果两组(研究与对照)结果差异显著的指标分别为:自然杀伤(NK)细胞9.26%±5.98%对12.19%±5.80%,P<0.05;CD4/CD8细胞比值0.39±0.21对0.53±0.24,P<0.05;CD3细胞74.99%±10.33%对68.42%±8.82%,P<0.05;CD8细胞52.28%±12.59%对43.58%±10.99%,P<0.05;丙氨酸氨酶(ALT)(48.59±40.21)U/L对(26.87±27.23)U/L,P<0.01;天冬氨酸转氨酶(AST)(61.66±51.02)U/L对(34.17±30.24)U/L,P<0.001;谷氨酰转肽酶(GGT)(136.50±111.50)U/L对(43.88±36.17)U/L,P<0.001;甘胆酸(CG)(683.41±962.22)μg/L对(250.96±290.81)μg/L,P<0.001;透明质酸(HA)(180.94±196.69)ng/ml对(64.68±32.74)ng/ml,P<0.001;白/球蛋白(A/G)比值1.35±0.24对1.50±0.34,P<0.05。与单独HIV感染者比较,HIV/HCV混合感染者的NK细胞、CD4/CD8细胞比值和A/G比值显著降低,而ALT、AST、GGT、CG和HA的水平显著增加。结论HIV/HCV混合感染可能加剧患者淋巴细胞亚群的不平衡,加重肝脏损伤和出现肝硬化趋势。
Objective To explore the characteristics of immune lymphocyte subpopulation and liver biochemical markers in patients with HIV/HCV co-infection.Methods Some related laboratory makers of peripheral blood in the study group （40 hemophiliac patients with HIV/HCV co-infection）and in the control group （ 12 hemophiliac patients with HIV infection only）were detected and analyzed.Results There were significant differences between results of the two groups （study and the control） were in following： NK cell （9.26± 5.98） % vs （ 12.19 ±5.80）%, P〈0.05. The rate of CIM/CD8 0.39±0.21 vs 0.53±0.24, P〈0.05. CD3 （74.99± 10.33）% vs （68.42± 8.82）%, P 〈0.05. 0）8 （52.28±12.59）% vs （43.58± 10.99）%, P 〈 0.05. ALT （48.59± 40.21）U/L vs （26.87 ± 27.23）U/L, P 〈 0.001. AST （61.66±51.02）U/L vs （34.17± 30.24）U/L, P〈0.001. GGT （136.50± 111.50）U/L vs （43.88 ± 36.17）U/L, P 〈 0.001. CG （683.41 ± 962.22）μg/dL vs （250.96± 290. 81）μg/dL, P 〈 0.001. Hyaluronic acid （ 180.94± 196.69）ng/mL vs （64.68 ± 32.74）ng/mL, P〈0.001. Albumin/globin （1.35±0.24） vs （1.50±0.34）, P 〈 0.05. Comparing with the patients infected with HIV only, NK ceil, rates of CD4/CD8 and albumin/globin were decreased significantly, but the level of AST, ALT, GGT , CG, and liver fibrosis marker HA were increased significantly in the patients co-infected with HIV/HCV.Conclusion Patients co-infected with HIV/HCV may aggravate the imbalance of lymphocyte subpopnlations, worsen liver injury and occur fibrosis tendency.
出处
《微生物与感染》
2007年第1期13-15,50,共4页
Journal of Microbes and Infections
