摘要
应用单克隆抗体铺皿法分离出ＣＤ４＋、ＣＤ８＋和Ｂ细胞，小剂量Ｘ射线照射前两种细胞，观察照后的ＣＤ４＋、ＣＤ８＋对Ｂ细胞３Ｈ－ＴｄＲ参入的影响。结果表明，正常ＣＤ４＋细胞对Ｂ细胞具有辅助作用，ＣＤ４＋细胞对Ｂ细胞具有抑制作用，小剂量照射可加强ＣＤ４＋对Ｂ细胞的辅助作用，促进ＣＤ８＋对Ｂ细胞的抑制作用，以０．１０Ｇｙ照射后这种效应最强，０．２０Ｇｙ照射后仍可观察到这种效应。
Monoclonal antibodies of anti CD4, anti CD8 and antiB wereused to separate CD4+, CD8+ and B lymphocyte subsets respectively. After low dose Xrays radistjon, the regulatory functions of CD4+ and CD8+ on B cell were studied by using 3H-TdR incorporation. The results indicated that CD4+ cell could increase the AH-TdR incorporation of B cell, CDS+ could decrease the 3H-TdR incorporation of B cell. Low dose radiation could enhance the helping effect of CD4+ and inhibitive effect of CD8+ on B cell at a dose range of 0.02-0.20 Gy, especially at the dose o f 0. 10 Gy X-rays radiation.
出处
《辐射研究与辐射工艺学报》
CAS
CSCD
北大核心
1994年第4期247-250,共4页
Journal of Radiation Research and Radiation Processing
关键词
小剂量辐射
淋巴细胞亚群
相互作用
Low dose radiation, Lymphocyte subsets, Inter-regulation, Biologi cal radiation effects
